Synthesis of 5-amino-1-aryl-4-(4-aryl-1,3-thiazol-2-yl)2,3-dihydro-1H-pyrrol-3-ones

被引：8
|
作者：
Volovenko, YM
Volovnenko, TA
Tverdokhlebov, AV
Ryabokon, IG
机构：
[1] Taras Shevchenko Kiev Natl Univ, UA-01033 Kiev, Ukraine
[2] Ukrainian State Univ Food Technol, Kiev, Ukraine
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 37卷 / 09期
关键词：
D O I：
10.1023/A:1013196008180
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reactions of 2-(4-aryl-1,3-thiazol-2-yl)-3-oxo-4-chlorobutyronitriles with primary aromatic amines result in nucleophilic substitution of the chlorine atom by amino group, followed by intramolecular addition of the secondary amino group to the cyano group. The products are 5-amino-1-aryl-4-(4-aryl-1,3-thiazol-2-yl)2,3-dihydro-1H-pyrrol-3-ones which are structurally related to the known antiischemic drugs.
引用
收藏
页码：1323 / 1329
页数：7
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