Synthesis of 5-amino-1-aryl-4-(4-aryl-1,3-thiazol-2-yl)2,3-dihydro-1H-pyrrol-3-ones

被引：8

作者：

Volovenko, YM

Volovnenko, TA

Tverdokhlebov, AV

Ryabokon, IG

机构：

[1] Taras Shevchenko Kiev Natl Univ, UA-01033 Kiev, Ukraine

[2] Ukrainian State Univ Food Technol, Kiev, Ukraine

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 37卷 / 09期

关键词：

D O I：

10.1023/A:1013196008180

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions of 2-(4-aryl-1,3-thiazol-2-yl)-3-oxo-4-chlorobutyronitriles with primary aromatic amines result in nucleophilic substitution of the chlorine atom by amino group, followed by intramolecular addition of the secondary amino group to the cyano group. The products are 5-amino-1-aryl-4-(4-aryl-1,3-thiazol-2-yl)2,3-dihydro-1H-pyrrol-3-ones which are structurally related to the known antiischemic drugs.

引用

页码：1323 / 1329

页数：7

共 14 条

[1]

BABICHEV FS, 1977, KHIM GETEROTSIKL+, P557

[2] NONPEPTIDE ANGIOTENSIN-II ANTAGONISTS - N-PHENYL-1H-PYRROLE DERIVATIVES ARE ANGIOTENSIN-II RECEPTOR ANTAGONISTS [J].

BOVY, PR ;

REITZ, DB ;

COLLINS, JT ;

CHAMBERLAIN, TS ;

OLINS, GM ;

CORPUS, VM ;

MCMAHON, EG ;

PALOMO, MA ;

KOEPKE, JP ;

SMITS, GJ ;

MCGRAW, DE ;

GAW, JF .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (01) :101-110

[3]

ELNAGDI MH, 1997, J CHEM RES M, P375

[4] ANTIPARASITIC AGENTS .5. SYNTHESIS AND ANTHELMINTIC ACTIVITIES OF NOVEL 2-HETEROAROMATIC-SUBSTITUTED ISOTHIOCYANATOBENZOXAZOLES AND BENZOTHIAZOLES [J].

HAUGWITZ, RD ;

ANGEL, RG ;

JACOBS, GA ;

MAURER, BV ;

NARAYANAN, VL ;

CRUTHERS, LR ;

SZANTO, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) :969-974

[5] INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS .2. 3,5-DIHYDROXY-7-(N-PYRROLYL)-6-HEPTENOATES, A NOVEL SERIES OF HMG-COA REDUCTASE INHIBITORS [J].

PROCOPIOU, PA ;

DRAPER, CD ;

HUTSON, JL ;

INGLIS, GGA ;

ROSS, BC ;

WATSON, NS .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (23) :3658-3662

[6]

Resnyanskaya EV, 1999, KHIM GETEROTSIKL+, P1412

[7] CHEMISTRY OF "4-PHENYL-THIAZOLYL-(2)-ACETONITRILE [J].

SCHAFER, H ;

GEWALD, K .

JOURNAL FUR PRAKTISCHE CHEMIE, 1974, 316 (04) :684-692

[8]

SEKO N, 1991, CHEM PHARM BULL, V39, P651

[9]

Tverdokhlebov AV, 1998, KHIM GETEROTSIKL+, P50

[10]

VOLOVENKO YM, 1979, UKR KHIM ZH+, V45, P857

← 1 2 →