Enzyme inhibition by allicin, the molluscicidal agent of Allium sativum L (garlic)

被引：0
|
作者：
Singh, VK [1 ]
Singh, DK [1 ]
机构：
[1] GORAKHPUR UNIV, DEPT ZOOL, GORAKHPUR 273009, UTTAR PRADESH, INDIA
来源：
PHYTOTHERAPY RESEARCH | 1996年 / 10卷 / 05期
关键词：
allicin; enzyme; snail; Allium sativum;
D O I：
10.1002/(SICI)1099-1573(199608)10:5<383::AID-PTR855>3.0.CO;2-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Allicin, a molluscicidal component of garlic inhibited the activity of acetylcholinesterase, lactic dehydrogenase and alkaline phosphatase in in vivo and in vitro exposure against Lymnaea acuminata, It was observed that succinic dehydrogenase activity in the nervous tissue of Lymnaea acuminata was increased in in vivo treatment whereas with in vitro exposure, allicin caused no significant change in succinic dehydrogenase activity. The inhibition kinetics of these enzymes indicates that allicin caused an uncompetitive inhibition of AChE and a competitive inhibition of LDH and alkaline phosphatase.
引用
收藏
页码：383 / 386
页数：4
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