Assessment of β-cell function in human patients

被引：19

作者：

Choi, Cheol Soo ^{[2
,3
]}

Kim, Mi Yeon ^{[1
]}

Han, Kyungreem ^{[4
,5
]}

Lee, Myung-Shik ^{[1
,6
]}

机构：

[1] Seoul Natl Univ, Samsung Med Ctr, Dept Med, Seoul, South Korea

[2] Gachon Univ Med & Sci, Lee Gil Ya Canc & Diabet Inst, Inchon, South Korea

[3] Gachon Univ Med & Sci, Gil Med Ctr, Div Endocrinol, Inchon, South Korea

[4] Seoul Natl Univ, Coll Pharm, Seoul, South Korea

[5] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul, South Korea

[6] Sungkyunkwan Univ, Sch Med, Samsung Adv Inst Hlth Sci & Technol, Seoul, South Korea

来源：

ISLETS | 2012年 / 4卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

type 2 diabetes mellitus; insulin resistance; glucose tolerance test; glucose clamp technique; INSULIN-SECRETION RATE; GLUCOSE-TOLERANCE; C-PEPTIDE; INTRAVENOUS GLUCOSE; MINIMAL MODEL; DYSFUNCTION; RESISTANCE; PATHOGENESIS; STIMULATION; SENSITIVITY;

D O I：

10.4161/isl.19270

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review focuses on the methods accessing beta-cell function. beta-cell failure is the critical step in the development of type 2 diabetes. Therefore, assessment of beta-cell function is an important part of the evaluation and treatment of diabetic patients. However, it is not easy because of complex interaction between multiple tissues. Several parameters should be considered, such as glucose level and insulin sensitivity of diverse insulin target tissues to assess beta-cell function. To overcome these difficulties, several invasive or non- invasive methods have been developed to assess beta-cell function for clinical or research purposes.

引用

页码：79 / 83

页数：5

共 39 条

[21] Regulation of β-cell mass by hormones and growth factors
Nielsen, JH
Galsgaard, ED
Moldrup, A
Friedrichsen, BN
Billestrup, N
Hansen, JA
Lee, YC
Carlsson, C
[J]. DIABETES, 2001, 50 : S25 - S29
[22] Evaluation of Beta Cell Dysfunction by Mixed Meal Tolerance Test and Oral L-arginine in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
Ozbek, M.
Erdogan, M.
Karadeniz, M.
Cetinkalp, S.
Ozgen, A. G.
Saygili, F.
Yilmaz, C.
Tuzun, M.
[J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2009, 117 (10) : 573 - 576
[23] PFEIFER MA, 1981, DIABETOLOGIA, V21, P198
[24] DIFFERENTIAL-EFFECTS OF TOLBUTAMIDE ON 1ST AND 2ND PHASE INSULIN-SECRETION IN NONINSULIN-DEPENDENT DIABETES-MELLITUS
PFEIFER, MA
HALTER, JB
BEARD, JC
PORTE, D
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 53 (06) : 1256 - 1262
[25] Effects of meal size and composition on incretin, α-cell, and β-cell responses
Rijkelijkhuizen, Josina M.
McQuarrie, Kelly
Girman, Cynthia J.
Stein, Peter P.
Mari, Andrea
Holst, Jens J.
Nijpels, Giel
Dekker, Jacqueline M.
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2010, 59 (04): : 502 - 511
[26] METABOLISM OF PROINSULIN AND INSULIN BY LIVER
RUBENSTEIN, AH
STEINER, DF
MAKO, M
GETZ, GS
POTTENGER, LA
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1972, 51 (04) : 912 - +
[27] Gastrectomy induces impaired insulin and glucagon secretion:: evidence for a gastro-insular axis in mice
Salehi, A
Chen, D
Håkanson, R
Nordin, G
Lundquist, I
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1999, 514 (02): : 579 - 591
[28] A stochastic deconvolution method to reconstruct insulin secretion rate after a glucose stimulus
Sparacino, G
Cobelli, C
[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1996, 43 (05) : 512 - 529
[29] The insulin secretory granule as a signaling hub
Suckalel, Jakob
Solimena, Michele
[J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2010, 21 (10) : 599 - 609
[30] Successful islet autotransplantation in humans - Functional insulin secretory reserve as an estimate of surviving islet cell mass
Teuscher, AU
Kendall, DM
Smets, YFC
Leone, JP
Sutherland, DER
Robertson, RP
[J]. DIABETES, 1998, 47 (03) : 324 - 330

← 1 2 3 4 →