Assessment of β-cell function in human patients

被引：19
作者：
Choi, Cheol Soo [2 ,3 ]
Kim, Mi Yeon [1 ]
Han, Kyungreem [4 ,5 ]
Lee, Myung-Shik [1 ,6 ]
机构：
[1] Seoul Natl Univ, Samsung Med Ctr, Dept Med, Seoul, South Korea
[2] Gachon Univ Med & Sci, Lee Gil Ya Canc & Diabet Inst, Inchon, South Korea
[3] Gachon Univ Med & Sci, Gil Med Ctr, Div Endocrinol, Inchon, South Korea
[4] Seoul Natl Univ, Coll Pharm, Seoul, South Korea
[5] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul, South Korea
[6] Sungkyunkwan Univ, Sch Med, Samsung Adv Inst Hlth Sci & Technol, Seoul, South Korea
来源：
ISLETS | 2012年 / 4卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
type 2 diabetes mellitus; insulin resistance; glucose tolerance test; glucose clamp technique; INSULIN-SECRETION RATE; GLUCOSE-TOLERANCE; C-PEPTIDE; INTRAVENOUS GLUCOSE; MINIMAL MODEL; DYSFUNCTION; RESISTANCE; PATHOGENESIS; STIMULATION; SENSITIVITY;
D O I：
10.4161/isl.19270
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This review focuses on the methods accessing beta-cell function. beta-cell failure is the critical step in the development of type 2 diabetes. Therefore, assessment of beta-cell function is an important part of the evaluation and treatment of diabetic patients. However, it is not easy because of complex interaction between multiple tissues. Several parameters should be considered, such as glucose level and insulin sensitivity of diverse insulin target tissues to assess beta-cell function. To overcome these difficulties, several invasive or non- invasive methods have been developed to assess beta-cell function for clinical or research purposes.
引用
收藏
页码：79 / 83
页数：5
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