Secreted 70 kDa lumican stimulates growth and inhibits invasion of human pancreatic cancer

被引：37

作者：

Yamamoto, Tetsushi

Matsuda, Yoko

Kawahara, Kiyoko

Ishiwata, Toshiyuki ^{[1
]}

Naito, Zenya

机构：

[1] Nippon Med Sch, Dept Pathol, Bunkyo Ku, Tokyo 1138602, Japan

来源：

CANCER LETTERS | 2012年 / 320卷 / 01期

基金：

日本学术振兴会;

关键词：

Pancreatic ductal adenocarcinoma; Lumican; Small leucine-rich proteoglycan; Cell growth; Cell invasion; KERATAN SULFATE PROTEOGLYCAN; LEUCINE-RICH PROTEOGLYCAN; NONFUCOSYLATED THERAPEUTIC ANTIBODIES; SMOOTH-MUSCLE CELLS; COLLAGEN FIBRILLOGENESIS; EXTRACELLULAR-MATRIX; NEXT-GENERATION; EXPRESSION; METASTASIS; CD44;

D O I：

10.1016/j.canlet.2012.01.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lumican expression in the stromal tissues of pancreatic ductal adenocarcinoma (PDAC) correlates with tumor invasion, and tends to correlate with poor prognosis. We used gene transfection techniques to examine the biological roles of lumican secreted from PDAC cells. Lumican-transfected PANC-1 cells secreted a 70-kDa lumican protein and had an active ERK pathway. Transfection stimulated PANC-1 cell growth, increased cell adhesion to laminin, inhibited cell invasion, and decreased active matrix metalloproteinase-9. Down-regulation of lumican using siRNA resulted in opposite cell behavior. Thus, the 70-kDa lumican secreted by PDAC cells plays important roles in cell growth and invasion. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：31 / 39

页数：9

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