Telomerase Regulation from Beginning to the End

被引：60
作者：
MacNeil, Deanna Elise [1 ,2 ]
Bensoussan, Helene Jeanne [1 ,2 ]
Autexier, Chantal [1 ,2 ,3 ]
机构：
[1] Jewish Gen Hosp, Bloomfield Ctr Res Aging, Lady Davis Inst Med Res, 3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada
[2] McGill Univ, Dept Anat & Cell Biol, Room M-29,3640 Univ St, Montreal, PQ H3A 0C7, Canada
[3] McGill Univ, Dept Expt Med, 1110 Pins Ave West,Room 101, Montreal, PQ H3A 1A3, Canada
来源：
GENES | 2016年 / 7卷 / 09期
关键词：
telomerase; telomere; H; ACA ribonucleoprotein; small nucleolar RNA; small Cajal body RNA; spliceosome; exosome; REVERSE-TRANSCRIPTASE HTERT; H/ACA SMALL NUCLEOLAR; DYSKERATOSIS-CONGENITA MUTATIONS; HOYERAAL-HREIDARSSON SYNDROME; TERT PROMOTER MUTATIONS; CHROMATIN-REMODELING COMPLEX; BODY-SPECIFIC LOCALIZATION; NONCODING RNA TERRA; N-TERMINAL DOMAIN; BOX H/ACA;
D O I：
10.3390/genes7090064
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The vast body of literature regarding human telomere maintenance is a true testament to the importance of understanding telomere regulation in both normal and diseased states. In this review, our goal was simple: tell the telomerase story from the biogenesis of its parts to its maturity as a complex and function at its site of action, emphasizing new developments and how they contribute to the foundational knowledge of telomerase and telomere biology.
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页数：33
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共 251 条
  • [1] The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids
    Akiyama, Benjamin M.
    Parks, Joseph W.
    Stone, Michael D.
    [J]. NUCLEIC ACIDS RESEARCH, 2015, 43 (11) : 5537 - 5549
  • [2] Akiyama M, 2003, CANCER RES, V63, P18
  • [3] Aldous WK, 1999, CANCER, V85, P1523, DOI 10.1002/(SICI)1097-0142(19990401)85:7<1523::AID-CNCR13>3.0.CO
  • [4] 2-P
  • [5] N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo
    Armbruster, BN
    Banik, SSR
    Guo, CH
    Smith, AC
    Counter, CM
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (22) : 7775 - 7786
  • [6] Biology of EWS/ETS fusions in Ewing's family tumors
    Arvand, A
    Denny, CT
    [J]. ONCOGENE, 2001, 20 (40) : 5747 - 5754
  • [7] Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA
    Autexier, C
    Pruzan, R
    Funk, WD
    Greider, CW
    [J]. EMBO JOURNAL, 1996, 15 (21) : 5928 - 5935
  • [8] The structure and function of telomerase reverse transcriptase
    Autexier, Chantal
    Lue, Neal F.
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 : 493 - 517
  • [9] TERRA mimicking ssRNAs prevail over the DNA substrate for telomerase in vitro due to interactions with the alternative binding site
    Azhibek, Dulat
    Skvortsov, Dmitry
    Andreeva, Anna
    Zatsepin, Timofei
    Arutyunyan, Alexandr
    Zvereva, Maria
    Dontsova, Olga
    [J]. JOURNAL OF MOLECULAR RECOGNITION, 2016, 29 (06) : 242 - 247
  • [10] Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells
    Azouz, A.
    Wu, Y-L
    Hillion, J.
    Tarkanyi, I.
    Karniguian, A.
    Aradi, J.
    Lanotte, M.
    Chen, G-Q
    Chehna, M.
    Segal-Bendirdjian, E.
    [J]. LEUKEMIA, 2010, 24 (03) : 613 - 622
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