An efficient, palladium-catalysed, amination of aryl bromides

被引：100

作者：

Guari, Y ^{[1
]}

van Es, DS ^{[1
]}

Reek, JNH ^{[1
]}

Kamer, PCJ ^{[1
]}

van Leeuwen, PWNM ^{[1
]}

机构：

[1] Univ Amsterdam, Inst Mol Chem, NL-1018 WV Amsterdam, Netherlands

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 19期

关键词：

palladium and compounds; phosphanes; catalysis; amines; arylation;

D O I：

10.1016/S0040-4039(99)00527-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aryl bromides are coupled to primary aliphatic amines, anilines and cyclic secondary amines in an efficient and selective procedure using catalytic amounts of Pd(OAc)(2) and the chelating ligand 9,9-dimethyl-4,6-bis(diphenylphosphino)xanthene (Xantphos). This catalyst system accomodating low catalyst loadings (0.5 mol % Pd) allows amination of both electron-poor and electron-rich aryl bromides. Even sterically crowded substrates show good reactivity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3789 / 3790

页数：2

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