Mesenchymal stem cell therapy in horses: useful beyond orthopedic injuries?

被引：40

作者：

De Schauwer, Catharina ^{[1
]}

Van de Walle, Gerlinde R. ^{[2
]}

Van Soom, Ann ^{[1
]}

Meyer, Evelyne ^{[3
]}

机构：

[1] Univ Ghent, Fac Vet Med, Dept Reprod Obstet & Herd Hlth, Merelbeke, Belgium

[2] Cornell Univ, Coll Vet Med, Baker Inst Anim Hlth, Ithaca, NY 14853 USA

[3] Univ Ghent, Fac Vet Med, Biochem Lab, Merelbeke, Belgium

来源：

VETERINARY QUARTERLY | 2013年 / 33卷 / 04期

关键词：

equine; horse; mesenchymal stem cells; orthopedic applications; non-orthopedic applications; stem cell therapy; DIGITAL FLEXOR TENDON; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE-RENAL-FAILURE; BONE-MARROW; RAT MODEL; REGENERATIVE MEDICINE; RECURRENT UVEITIS; CARTILAGE REPAIR; IMMUNE TOLERANCE; STROMAL CELLS;

D O I：

10.1080/01652176.2013.800250

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In the past decade, mesenchymal stem cells (MSC) have received much attention in equine veterinary medicine. The first therapeutic use of equine MSC was reported in 2003. Since then, the clinical application of MSC has been exploding with thousands of horses now treated worldwide. At present, MSC are mainly used in veterinary medicine to treat musculoskeletal diseases based on their ability to differentiate into various tissues of mesodermal origin. This is in marked contrast to human medicine, where MSC therapies are primarily focused on immune-mediated, inflammatory, and ischemic diseases. In this review, both orthopedic as well as non-orthopedic clinical applications of equine MSC are discussed. A brief overview is provided on the potential of MSC for non-orthopedic injuries with emphasis on those diseases, which occur in both humans and horses.

引用

页码：234 / 241

页数：8

共 84 条

[1] Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration [J].

Agung, Muhammad ;

Ochi, Mitsuo ;

Yanada, Shinobu ;

Adachi, Nobuo ;

Izuta, Yasunori ;

Yamasaki, Takuma ;

Toda, Katsuhiro .

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2006, 14 (12) :1307-1314

[2]

Alfaqeh H, 2008, Med J Malaysia, V63 Suppl A, P37

[3] Cell-based Therapies for Tendon and Ligament Injuries [J].

Alves, A. G. L. ;

Stewart, Allison A. ;

Dudhia, J. ;

Kasashima, Y. ;

Goodship, A. E. ;

Smith, R. K. W. .

VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 2011, 27 (02) :315-+

[4] Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway [J].

Augello, A ;

Tasso, R ;

Negrini, SM ;

Amateis, A ;

Indiveri, F ;

Cancedda, R ;

Pennesi, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1482-1490

[5] Treatment of chronic wounds with bone marrow-derived cells [J].

Badiavas, EV ;

Falanga, V .

ARCHIVES OF DERMATOLOGY, 2003, 139 (04) :510-516

[6] The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease [J].

Borjesson, Dori L. ;

Peroni, John F. .

CLINICS IN LABORATORY MEDICINE, 2011, 31 (01) :109-+

[7] Stem cell-based tissue engineering in veterinary orthopaedics [J].

Brehm, Walter ;

Burk, Janina ;

Delling, Uta ;

Gittel, Claudia ;

Ribitsch, Iris .

CELL AND TISSUE RESEARCH, 2012, 347 (03) :677-688

[8] The effect of intralesional injection of bone marrow derived mesenchymal stem cells and bone marrow supernatant on collagen fibril size in a surgical model of equine superficial digital flexor tendonitis [J].

Caniglia, C. J. ;

Schramme, M. C. ;

Smith, R. K. .

EQUINE VETERINARY JOURNAL, 2012, 44 (05) :587-593

[9]

Carstanjen B, 2006, CAN J VET RES, V70, P143

[10] Use of Adipose Tissue-Derived Mesenchymal Stem Cells for Experimental Tendinitis Therapy in Equines [J].

Carvalho, Armando de Mattos ;

Garcia Alves, Ana Liz ;

Gomes de Oliveira, Patricia Galvao ;

Cisneros Alvarez, Luis Emiliano ;

Amorim, Renee Laufer ;

Hussni, Carlos Alberto ;

Deffune, Elenice .

JOURNAL OF EQUINE VETERINARY SCIENCE, 2011, 31 (01) :26-34

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