Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent

被引：50

作者：

Fernandez-Rhodes, Lindsay ^{[12
]}

Demerath, Ellen W. ^{[28
]}

Cousminer, Diana L. ^{[40
]}

Tao, Ran ^{[7
]}

Dreyfus, Jill G. ^{[28
]}

Esko, Tonu ^{[8
,32
]}

Smith, Albert V. ^{[37
]}

Gudnason, Vilmundur ^{[37
]}

Harris, Tamara B. ^{[42
]}

Launer, Lenore ^{[42
]}

McArdle, Patrick F. ^{[18
,47
]}

Yerges-Armstrong, Laura M. ^{[18
,47
]}

Elks, Cathy E. ^{[43
]}

Strachan, David P. ^{[30
]}

Kutalik, Zoltan ^{[17
,51
]}

Vollenweider, Peter ^{[19
]}

Feenstra, Bjarke ^{[10
]}

Boyd, Heather A. ^{[10
]}

Metspalu, Andres ^{[8
,32
]}

Mihailov, Evelin ^{[8
,32
]}

Broer, Linda ^{[11
,45
]}

Zillikens, M. Carola ^{[15
,45
]}

Oostra, Ben ^{[9
]}

van Duijn, Cornelia M. ^{[11
,45
]}

Lunetta, Kathryn L. ^{[6
]}

Perry, John R. B. ^{[2
,24
,35
,53
]}

Murray, Anna ^{[35
]}

Koller, Daniel L. ^{[16
]}

Lai, Dongbing ^{[16
]}

Corre, Tanguy ^{[27
,29
]}

Toniolo, Daniela ^{[27
,29
]}

Albrecht, Eva ^{[39
]}

Stoeckl, Doris ^{[21
,38
]}

Grallert, Harald ^{[48
]}

Gieger, Christian ^{[39
]}

Hayward, Caroline ^{[44
]}

Polasek, Ozren ^{[4
,33
]}

Rudan, Igor ^{[3
]}

Wilson, James F. ^{[3
]}

He, Chunyan ^{[23
]}

Kraft, Peter ^{[20
]}

Hu, Frank B. ^{[20
]}

Hunter, David J. ^{[20
]}

Hottenga, Jouke-Jan ^{[5
,46
]}

Willemsen, Gonneke ^{[5
,46
]}

Boomsma, Dorret I. ^{[5
,46
]}

Byrne, Enda M. ^{[34
,52
]}

Martin, Nicholas G. ^{[34
]}

Montgomery, Grant W. ^{[34
]}

Warrington, Nicole M. ^{[49
]}

机构：

[1] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA

[2] Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA

[3] Univ Edinburgh, Coll Med & Vet Med, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland

[4] Univ Split, Sch Med, Dept Publ Hlth, Split, Croatia

[5] Vrije Univ Amsterdam, Dept Biol Psychol, Fac Psychol & Educ, Amsterdam, Netherlands

[6] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[7] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[8] Univ Tartu, Inst Mol & Cell Biol, Dept Biotechnol, EE-50090 Tartu, Estonia

[9] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

[10] Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark

[11] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[12] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[13] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC USA

[14] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA

[15] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[16] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN USA

[17] Univ Lausanne, Fac Biol & Med, Dept Med Genet, Lausanne, Switzerland

[18] Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

[19] Univ Vaudois, Ctr Hosp, Internal Med Unit, Dept Med, Lausanne, Switzerland

[20] Harvard Univ, Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA

[21] Univ Munich, Dept Obstet & Gynaecol, Munich, Germany

[22] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[23] Indiana Univ, Sch Med, Dept Publ Hlth, Indianapolis, IN 46202 USA

[24] Kings Coll London, Sch Med, Dept Twin Res & Genet Epidemiol, Div Genet & Mol Med, London, England

[25] Univ Sassari, Fac Med & Surg, Dept Biomed Sci, I-07100 Sassari, Italy

[26] Mem Univ Newfoundland, Fac Med, Discipline Genet, St John, NF, Canada

[27] Ist Sci San Raffaele, Div Cell Biol, I-20132 Milan, Italy

[28] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[29] Ist Sci San Raffaele, Div Genet, I-20132 Milan, Italy

[30] Univ London, Sch Med, St Georges Hosp, Div Populat Hlth Sci & Educ, London, England

[31] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA

[32] Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia

[33] Gen Info Ltd, Zagreb, Croatia

[34] Queensland Inst Med Res, Genet Epidemiol Mol Epidemiol & Neurogenet Labs, Brisbane, Qld 4006, Australia

[35] Univ Exeter, Peninsula Med Sch, Genet Complex Traits Res Grp, Exeter, Devon, England

[36] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[37] Iceland Heart Assoc, Reykjavik, Iceland

[38] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany

[39] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany

[40] Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland

[41] CNR, Ist Ric Genet & Biomed, Cagliari, Italy

[42] NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[43] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England

[44] Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

[45] Netherlands Genom Initiat, Netherlands Consortium Hlth Aging, Leiden, Netherlands

[46] Netherlands Twin Register, Amsterdam, Netherlands

[47] Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA

[48] German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany

[49] Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia

[50] Boston Univ, Sch Med, Dept Med, Gen Internal Med Sect, Boston, MA 02118 USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2013年 / 178卷 / 03期

基金：

英国惠康基金;

关键词：

adiposity; body mass index; genetic association studies; menarche; obesity; waist circumference; waist:hip ratio; womens health; GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; WAIST CIRCUMFERENCE; SEQUENCE VARIANTS; AGE; LOCI; OBESITY; METAANALYSIS; WEIGHT; RISK;

D O I：

10.1093/aje/kws473

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)(2)), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (19702010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 917 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development.

引用

页码：451 / 460

页数：10

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