Acidic and basic fibroblast growth factors improve spatial learning impaired by fimbria-fornix lesion in rat

被引：2

作者：

Amino, H ^{[1
]}

Saito, H ^{[1
]}

Nishiyama, N ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, DEPT CHEM PHARMACOL, TOKYO 113, JAPAN

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 1996年 / 72卷 / 04期

关键词：

septo-hippocampal cholinergic pathway; nerve growth factor (NGF); Y-maze test; water maze test; learning deficit;

D O I：

10.2183/pjab.72.67

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Effects of acidic and basic fibroblast growth factors (a- and bFGFs, respectively) on spatial learning performance of fimbria-fornix (FF)-lesioned rats were investigated in Y-maze and water maze tests. Transection of FF produced severe spatial memory deficits revealed by both tests. Intracerebroventricular (i.c.v.) injection of aFGF (100-400 ng/rat) and bFGF (100-400 ng/rat) 30 min before the daily session significantly improved the spatial learning impairments induced by FF-lesion in both types of spatial learning tasks. In contrast, i.c.v. injection of nerve growth factor (NGF, 100-400 ng/rat) did not ameliorate the spatial learning performance in FF-lesioned rats. This is the first report providing direct evidence that both aFCF and bFGF improve the spatial learning impaired by loss of septo-hippocampal cholinergic afferents.

引用

页码：67 / 72

页数：6

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