Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment

被引：31
|
作者：
Morise, B. T. [1 ]
Chagas, A. L. D. [1 ,2 ]
Barros, N. R. [1 ,2 ]
Miranda, M. C. R. [1 ]
Borges, F. A. [1 ,2 ]
Gemeinder, J. L. P. [2 ]
Silva, R. G. [2 ]
Paulino, C. G. [1 ]
Herculano, R. D. [1 ]
Norberto, A. M. Q. [3 ]
机构：
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara Km 01,Araraquara Jau Rd, BR-14801902 Araraquara, Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, 55 Prof Francisco Degni St, BR-14800900 Araraquara, Brazil
[3] Univ Sao Paulo, Fac Med, Ribeirao Preto, Brazil
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 13期
基金：
巴西圣保罗研究基金会;
关键词：
Sialorrhea; scopolamine; natural rubber latex; sustained release; biomaterial; RELEASE; DELIVERY;
D O I：
10.1080/00914037.2018.1506984
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.
引用
收藏
页码：788 / 795
页数：8
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