Acitretin in dermatology

被引：60

作者：

Sarkar, Rashmi ^{[1
]}

Chugh, Shikha ^{[1
]}

Garg, Vijay K. ^{[1
]}

机构：

[1] Maulana Azad Med Coll, Dept Dermatol, New Delhi 110092, India

来源：

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY | 2013年 / 79卷 / 06期

关键词：

Acitretin; chemoprevention; psoriasis; SQUAMOUS-CELL CARCINOMA; LOW-DOSE ACITRETIN; DOUBLE-BLIND; ORAL RETINOIDS; COMBINATION THERAPY; LICHEN-PLANUS; GOOD RESPONSE; BASAL-CELL; PSORIASIS; ETRETINATE;

D O I：

10.4103/0378-6323.120721

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Acitretin, a synthetic retinoid has gradually replaced etretinate in today's dermatologic practice because of its more favorable pharmacokinetics. Acitretin over the past 20 years has proven useful in a number of difficult-to-treat hyperkeratotic and inflammatory dermatoses and nonmelanoma skin cancers. It is effective both as monotherapy and in combination with other drugs for hyperkeratotic disorders. It is considered to be an established second line treatment for psoriasis and exerts its effect mainly due to its antikeratinizing, antiinflammatory, and antiproliferative effect. Its antineoplastic properties make it a useful agent for cancer prophylaxis. Evidence-based efficacy, side-effect profile, and approach to the use of acitretin would be discussed in this review. In addition to its approved uses, the various off label uses will also be highlighted in this section. Since its use is limited by its teratogenic potential and other adverse effects, including mucocutaneous effects and hepatotoxicity, this review would summarize the contraindications and precautions to be exercised before prescribing acitretin.

引用

页码：759 / 771

页数：13

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