Optical Control of TRPV1 Channels

被引：52

作者：

Stein, Marco ^{[1
,2
]}

Breit, Andreas ^{[3
]}

Fehrentz, Timm ^{[1
,2
]}

Gudermann, Thomas ^{[3
]}

Trauner, Dirk ^{[1
,2
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

[2] Ctr Integrated Prot Sci, D-81377 Munich, Germany

[3] Ludwig Maximilians Univ Munchen, Walther Straub Inst Pharmacol & Toxicol, D-80336 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 37期

关键词：

azobenzenes; capsaicin; capsazepine; photopharmacology; TRPV1; IONOTROPIC GLUTAMATE RECEPTORS; CAPSAICIN RECEPTOR; ION-CHANNEL; VISUAL RESPONSES; ACTIVATION; RESINIFERATOXIN; PHOTOSWITCH; CAPSAZEPINE; ANTAGONIST; ANANDAMIDE;

D O I：

10.1002/anie.201302530

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9845 / 9848

页数：4

共 42 条

[11]

Fortin DL, 2008, NAT METHODS, V5, P331, DOI [10.1038/NMETH.1187, 10.1038/nmeth.1187]

[12] Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor [J].

Gorostiza, Pau ;

Volgraf, Matthew ;

Numano, Rika ;

Szobota, Stephanie ;

Trauner, Dirk ;

Isacoff, Ehud Y. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (26) :10865-10870

[13] Light-evoked calcium responses of isolated melanopsin-expressing retinal ganglion cells [J].

Hartwick, Andrew T. E. ;

Bramley, Jayne R. ;

Yu, Jianing ;

Stevens, Kelly T. ;

Allen, Charles N. ;

Baldridge, William H. ;

Sollars, Patricia J. ;

Pickard, Gary E. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (49) :13468-13480

[14] Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances [J].

Hwang, SW ;

Cho, H ;

Kwak, J ;

Lee, SY ;

Kang, CJ ;

Jung, J ;

Cho, S ;

Min, KH ;

Suh, YG ;

Kim, D ;

Oh, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :6155-6160

[15] Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy [J].

Ito, Naoki ;

Ruegg, Urs T. ;

Kudo, Akira ;

Miyagoe-Suzuki, Yuko ;

Takeda, Shin'ichi .

NATURE MEDICINE, 2013, 19 (01) :101-106

[16] A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing [J].

Janovjak, Harald ;

Szobota, Stephanie ;

Wyart, Claire ;

Trauner, Dirk ;

Isacoff, Ehud Y. .

NATURE NEUROSCIENCE, 2010, 13 (08) :1027-U160

[17]

Kokel D., 2013, NAT CHEM BIOL

[18] A facile and practical synthesis of capsazepine, a vanilloid receptor antagonist [J].

Lee, J ;

Lee, J .

SYNTHETIC COMMUNICATIONS, 1999, 29 (23) :4127-4140

[19] Optical control of metabotropic glutamate receptors [J].

Levitz, Joshua ;

Pantoja, Carlos ;

Gaub, Benjamin ;

Janovjak, Harald ;

Reiner, Andreas ;

Hoagland, Adam ;

Schoppik, David ;

Kane, Brian ;

Stawski, Philipp ;

Schier, Alexander F. ;

Trauner, Dirk ;

Isacoff, Ehud Y. .

NATURE NEUROSCIENCE, 2013, 16 (04) :507-U190

[20] Voltage is a partial activator of rat thermosensitive TRP channels [J].

Matta, Jose A. ;

Ahern, Gerard P. .

JOURNAL OF PHYSIOLOGY-LONDON, 2007, 585 (02) :469-482

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