NEURO-ONCOLOGY In search of molecular markers of glioma in elderly patients

被引：9

作者：

Hegi, Monika E. ^{[1
]}

Stupp, Roger ^{[2
,3
]}

机构：

[1] Univ Lausanne Hosp, Dept Clin Neurosci, CH-1011 Lausanne, Switzerland

[2] Univ Zurich Hosp, Dept Oncoloy, CH-8091 Zurich, Switzerland

[3] Univ Zurich Hosp, Ctr Canc, CH-8091 Zurich, Switzerland

来源：

NATURE REVIEWS NEUROLOGY | 2013年 / 9卷 / 08期

关键词：

TEMOZOLOMIDE; MUTATIONS; GLIOBLASTOMA; RADIOTHERAPY; TUMORS; CELLS;

D O I：

10.1038/nrneurol.2013.127

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Elderly patients represent a growing proportion of individuals with malignant glioma, but are often excluded from trials owing to their poor prognosis. In a new study, researchers have investigated molecular markers of glioma specifically in elderly patients-are these markers of clinical use?

引用

页码：424 / 425

页数：2

共 10 条

[1] Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients [J].

Agnihotri, Sameer ;

Gajadhar, Aaron S. ;

Ternamian, Christian ;

Gorlia, Thierry ;

Diefes, Kristin L. ;

Mischel, Paul S. ;

Kelly, Joanna ;

McGown, Gail ;

Thorncroft, Mary ;

Carlson, Brett L. ;

Sarkaria, Jann N. ;

Margison, Geoffrey P. ;

Aldape, Kenneth ;

Hawkins, Cynthia ;

Hegi, Monika ;

Guha, Abhijit .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (01) :253-266

[2] Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN [J].

Bjerke, Lynn ;

Mackay, Alan ;

Nandhabalan, Meera ;

Burford, Anna ;

Jury, Alexa ;

Popov, Sergey ;

Bax, Dorine A. ;

Carvalho, Diana ;

Taylor, Kathryn R. ;

Vinci, Maria ;

Bajrami, Ilirjana ;

McGonnell, Imelda M. ;

Lord, Christopher J. ;

Reis, Rui M. ;

Hargrave, Darren ;

Ashworth, Alan ;

Workman, Paul ;

Jones, Chris .

CANCER DISCOVERY, 2013, 3 (05) :512-519

[3] Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro [J].

Dittmann, L. M. ;

Danner, A. ;

Gronych, J. ;

Wolter, M. ;

Stuehler, K. ;

Grzendowski, M. ;

Becker, N. ;

Bageritz, J. ;

Goidts, V. ;

Toedt, G. ;

Felsberg, J. ;

Sabel, M. C. ;

Barbus, S. ;

Reifenberger, G. ;

Lichter, P. ;

Tews, B. .

ONCOGENE, 2012, 31 (29) :3409-3418

[4] TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal [J].

Killela, Patrick J. ;

Reitman, Zachary J. ;

Jiao, Yuchen ;

Bettegowda, Chetan ;

Agrawal, Nishant ;

Diaz, Luis A., Jr. ;

Friedman, Allan H. ;

Friedman, Henry ;

Gallia, Gary L. ;

Giovanella, Beppino C. ;

Grollman, Arthur P. ;

He, Tong-Chuan ;

He, Yiping ;

Hruban, Ralph H. ;

Jallo, George I. ;

Mandahl, Nils ;

Meeker, Alan K. ;

Mertens, Fredrik ;

Netto, George J. ;

Rasheed, B. Ahmed ;

Riggins, Gregory J. ;

Rosenquist, Thomas A. ;

Schiffman, Mark ;

Shih, Ie-Ming ;

Theodorescu, Dan ;

Torbenson, Michael S. ;

Velculescu, Victor E. ;

Wang, Tian-Li ;

Wentzensen, Nicolas ;

Wood, Laura D. ;

Zhang, Ming ;

McLendon, Roger E. ;

Bigner, Darell D. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Papadopoulos, Nickolas ;

Yan, Hai .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (15) :6021-6026

[5] Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial [J].

Malmstrom, Annika ;

Gronberg, Bjorn Henning ;

Marosi, Christine ;

Stupp, Roger ;

Frappaz, Didier ;

Schultz, Henrik ;

Abacioglu, Ufuk ;

Tavelin, Bjorn ;

Lhermitte, Benoit ;

Hegi, Monika E. ;

Rosell, Johan ;

Henriksson, Roger .

LANCET ONCOLOGY, 2012, 13 (09) :916-926

[6]

Schwartzentruber J, 2012, NATURE, V482, P226, DOI [10.1038/nature10833, 10.1007/s13311-012-0137-6]

[7] Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma [J].

Sturm, Dominik ;

Witt, Hendrik ;

Hovestadt, Volker ;

Dong-Anh Khuong-Quang ;

Jones, David T. W. ;

Konermann, Carolin ;

Pfaff, Elke ;

Toenjes, Marge ;

Sill, Martin ;

Bender, Sebastian ;

Kool, Marcel ;

Zapatka, Marc ;

Becker, Natalia ;

Zucknick, Manuela ;

Hielscher, Thomas ;

Liu, Xiao-Yang ;

Fontebasso, Adam M. ;

Ryzhova, Marina ;

Albrecht, Steffen ;

Jacob, Karine ;

Wolter, Marietta ;

Ebinger, Martin ;

Schuhmann, Martin U. ;

van Meter, Timothy ;

Fruehwald, Michael C. ;

Hauch, Holger ;

Pekrun, Arnulf ;

Radlwimmer, Bernhard ;

Niehues, Tim ;

von Komorowski, Gregor ;

Duerken, Matthias ;

Kulozik, Andreas E. ;

Madden, Jenny ;

Donson, Andrew ;

Foreman, Nicholas K. ;

Drissi, Rachid ;

Fouladi, Maryam ;

Scheurlen, Wolfram ;

von Deimling, Andreas ;

Monoranu, Camelia ;

Roggendorf, Wolfgang ;

Herold-Mende, Christel ;

Unterberg, Andreas ;

Kramm, Christof M. ;

Felsberg, Joerg ;

Hartmann, Christian ;

Wiestler, Benedikt ;

Wick, Wolfgang ;

Milde, Till ;

Witt, Olaf .

CANCER CELL, 2012, 22 (04) :425-437

[8] IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype [J].

Turcan, Sevin ;

Rohle, Daniel ;

Goenka, Anuj ;

Walsh, Logan A. ;

Fang, Fang ;

Yilmaz, Emrullah ;

Campos, Carl ;

Fabius, Armida W. M. ;

Lu, Chao ;

Ward, Patrick S. ;

Thompson, Craig B. ;

Kaufman, Andrew ;

Guryanova, Olga ;

Levine, Ross ;

Heguy, Adriana ;

Viale, Agnes ;

Morris, Luc G. T. ;

Huse, Jason T. ;

Mellinghoff, Ingo K. ;

Chan, Timothy A. .

NATURE, 2012, 483 (7390) :479-U137

[9] Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial [J].

Wick, Wolfgang ;

Platten, Michael ;

Meisner, Christoph ;

Felsberg, Joerg ;

Tabatabai, Ghazaleh ;

Simon, Matthias ;

Nikkhah, Guido ;

Papsdorf, Kirsten ;

Steinbach, Joachim P. ;

Sabel, Michael ;

Combs, Stephanie E. ;

Vesper, Jan ;

Braun, Christian ;

Meixensberger, Juergen ;

Ketter, Ralf ;

Mayer-Steinacker, Regine ;

Reifenberger, Guido ;

Weller, Michael .

LANCET ONCOLOGY, 2012, 13 (07) :707-715

[10]

Wiestler B., NEURO-ONCOLOGY, DOI DOI 10.1093/NEU0NC/N0T043

← 1 →