Extending the window for thrombolysis for treatment of acute ischaemic stroke during pregnancy: a review

被引：5

作者：

Dinehart, E. ^{[1
]}

Leon Guerrero, C. ^{[2
]}

Pham, A. ^{[3
]}

Chandra, S. ^{[4
]}

Petersen, S. M. ^{[5
]}

Bathgate, S. ^{[5
]}

Ahmadzia, H. ^{[5
]}

机构：

[1] George Washington Univ, Sch Med & Hlth Sci, Dept Obstet & Gynecol, Washington, DC 20052 USA

[2] George Washington Univ, Sch Med & Hlth Sci, Dept Neurol, Washington, DC 20052 USA

[3] Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Nashville, TN 37232 USA

[4] Ohio State Univ, Coll Med, Columbus, OH 43210 USA

[5] George Washington Univ, Sch Med & Hlth Sci, Dept Obstet & Gynecol, Div Maternal Fetal Med, Washington, DC 20052 USA

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2021年 / 128卷 / 03期

关键词：

Acute ischaemic stroke; extended window; pregnancy; rt-PA; thrombolysis; GUIDELINES; ALTEPLASE; TIME;

D O I：

10.1111/1471-0528.16495

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Historically, safety of intravenous recombinant tissue plasminogen activator (IV rt-PA) for the treatment of acute ischaemic stroke (AIS) is limited to use within 4.5 hours from symptom onset. Recent studies suggest the treatment window may be extended when patients have salvageable brain tissue on advanced neuroimaging. This paper describes a novel use of IV rt-PA for treatment of AIS in a pregnant patient within an extended-time window (>4.5 hours, and <9 hours) based on advanced neuroimaging with a favourable outcome. Tweetable abstract Novel use of IV rt-PA for treatment of AIS in pregnancy within an extended-time window based on advanced imaging with a favourable outcome.

引用

页码：516 / 520

页数：5

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