Resveratrol reverts Streptozotocin-induced diabetic nephropathy

被引：15
|
作者：
Zhu, Huiping [1 ,2 ]
Zhong, Sen [1 ,2 ]
Yan, Haihong [1 ,2 ]
Wang, Kangyao [1 ,2 ]
Chen, Lingwei [1 ,2 ]
Zhou, Min [1 ,2 ]
Li, Yunsheng [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Peoples Hosp Wenling 1, Dept Nephrol, 333 Chuanan Rd, Wenling 317500, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Wenling Hosp, 333 Chuanan Rd, Wenling 317500, Zhejiang, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2020年 / 25卷
关键词：
Resveratrol; Renal dysfunction; Diabetic nephropathy; mTOR/ULK1; pathway; Autophagy; RENAL LIPID-METABOLISM; PODOCYTE FUNCTION; AUTOPHAGY; MICE; ACCUMULATION; PROGRESSION; PROTECTS; FIBROSIS; TARGET; MTOR;
D O I：
10.2741/4829
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetes causes diabetic nephropathy (DN) which is associated with increased morbidity and mortality in diabetic patients. We tested whether Resveratrol (Res) reverses the systemic effect of Streptozotocin (STZ) induced diabetes and DN. Res treatment opposed the effect of STZ on kidney weight, 24 h urinary albumin excretion, blood urea nitrogen (BUN) and serum creatinine (Scr). Res also decreased DN induced mTOR/ULK1-mediated autophagy and apoptosis and significantly reduced STZ mediated lipid deposition in nephrons, likely by decreasing the levels of lipogenic related proteins (SREBP-1c, ACS) and increased lipidolysis related proteins (PPAR alpha, CPT-1). Together, these findings show the potential of Res in prevention of diabetic nephropathy.
引用
收藏
页码：699 / 709
页数：11
相关论文
共 50 条
  • [1] RETRACTION: Resveratrol reverts Streptozotocin-induced diabetic nephropathy. Frontiers in Bioscience
    Zhu, H.
    Zhong, S.
    Yan, H.
    Wang, K.
    Chen, L.
    Zhou, M.
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2025, 30 (03):
  • [2] Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats
    Elbe, H.
    Vardi, N.
    Esrefoglu, M.
    Ates, B.
    Yologlu, S.
    Taskapan, C.
    HUMAN & EXPERIMENTAL TOXICOLOGY, 2015, 34 (01) : 100 - 113
  • [3] Rodent models of streptozotocin-induced diabetic nephropathy
    Tesch, Greg H.
    Allen, Terri J.
    NEPHROLOGY, 2007, 12 (03) : 261 - 266
  • [4] Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats
    Bahaa Al-Trad
    Ibraheem M. Ashankyty
    Mohd Alaraj
    Diabetology & Metabolic Syndrome, 7
  • [5] Taxifolin attenuates diabetic nephropathy in streptozotocin-induced diabetic rats
    Zhao, Yanling
    Huang, Wenwen
    Wang, Jiali
    Chen, Yan
    Huang, Wen
    Zhu, Yonglin
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 10 (04): : 1205 - 1210
  • [6] Transcriptomic Analysis in Diabetic Nephropathy of Streptozotocin-Induced Diabetic Rats
    Lomas-Soria, Consuelo
    Ramos-Gomez, Minerva
    Guevara-Olvera, Lorenzo
    Guevara-Gonzalez, Ramon
    Torres-Pacheco, Irineo
    Gallegos-Corona, Marco A.
    Reynoso-Camacho, Rosalia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (12) : 8431 - 8448
  • [7] Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats
    Al-Trad, Bahaa
    Ashankyty, Ibraheem M.
    Alaraj, Mohd
    DIABETOLOGY & METABOLIC SYNDROME, 2015, 7
  • [8] Protective effects of thymoquinone on streptozotocin-induced diabetic nephropathy
    Mehmet Kanter
    Journal of Molecular Histology, 2009, 40 : 107 - 115
  • [9] Prevention of nephropathy in streptozotocin-induced diabetic rats by thiamine
    Babaei-Jadidi, R
    Karachalias, N
    Thornalley, PJ
    DIABETES, 2002, 51 : A183 - A183
  • [10] Prevention of nephropathy in streptozotocin-induced diabetic rats by benfotiamine
    Karachalias, N
    Babaei-Jadidi, R
    Thornalley, P
    DIABETES, 2003, 52 : A481 - A481
12345