Resveratrol reverts Streptozotocin-induced diabetic nephropathy

被引：16

作者：

Zhu, Huiping ^{[1
,2
]}

Zhong, Sen ^{[1
,2
]}

Yan, Haihong ^{[1
,2
]}

Wang, Kangyao ^{[1
,2
]}

Chen, Lingwei ^{[1
,2
]}

Zhou, Min ^{[1
,2
]}

Li, Yunsheng ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Peoples Hosp Wenling 1, Dept Nephrol, 333 Chuanan Rd, Wenling 317500, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Wenling Hosp, 333 Chuanan Rd, Wenling 317500, Zhejiang, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2020年 / 25卷

关键词：

Resveratrol; Renal dysfunction; Diabetic nephropathy; mTOR/ULK1; pathway; Autophagy; RENAL LIPID-METABOLISM; PODOCYTE FUNCTION; AUTOPHAGY; MICE; ACCUMULATION; PROGRESSION; PROTECTS; FIBROSIS; TARGET; MTOR;

D O I：

10.2741/4829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes causes diabetic nephropathy (DN) which is associated with increased morbidity and mortality in diabetic patients. We tested whether Resveratrol (Res) reverses the systemic effect of Streptozotocin (STZ) induced diabetes and DN. Res treatment opposed the effect of STZ on kidney weight, 24 h urinary albumin excretion, blood urea nitrogen (BUN) and serum creatinine (Scr). Res also decreased DN induced mTOR/ULK1-mediated autophagy and apoptosis and significantly reduced STZ mediated lipid deposition in nephrons, likely by decreasing the levels of lipogenic related proteins (SREBP-1c, ACS) and increased lipidolysis related proteins (PPAR alpha, CPT-1). Together, these findings show the potential of Res in prevention of diabetic nephropathy.

引用

页码：699 / 709

页数：11

共 50 条

[1] Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats
Elbe, H.
Vardi, N.
Esrefoglu, M.
Ates, B.
Yologlu, S.
Taskapan, C.
HUMAN & EXPERIMENTAL TOXICOLOGY, 2015, 34 (01) : 100 - 113
[2] IL-17 deficiency aggravates the streptozotocin-induced diabetic nephropathy through the reduction of autophagosome formation in mice
Kim, Kyung-Hyun
Hong, Geum-Lan
Jung, Da-Young
Karunasagara, Shanika
Jeong, Won-Il
Jung, Ju-Young
MOLECULAR MEDICINE, 2021, 27 (01)
[3] Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats
Bahaa Al-Trad
Ibraheem M. Ashankyty
Mohd Alaraj
Diabetology & Metabolic Syndrome, 7
[4] Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats
Al-Trad, Bahaa
Ashankyty, Ibraheem M.
Alaraj, Mohd
DIABETOLOGY & METABOLIC SYNDROME, 2015, 7
[5] Resveratrol improves lipid metabolism in diabetic nephropathy rats
Zhao, Yong-hong
Fan, You-Jia
FRONTIERS IN BIOSCIENCE-LANDMARK, 2020, 25 : 1913 - 1924
[6] Comparative evaluation of torasemide and furosemide on rats with streptozotocin-induced diabetic nephropathy
Arumugam, Somasundaram
Sreedhar, Remya
Miyashita, Shizuka
Karuppagounder, Vengadeshprabhu
Thandavarayan, Rajarajan A.
Giridharan, Vijayasree V.
Pitchaimani, Vigneshwaran
Afrin, Rejina
Harima, Meilei
Suzuki, Kenji
Watanabe, Kenichi
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2014, 97 (01) : 137 - 143
[7] Effects of Resveratrol on the Kidney in Rats with Streptozotocin Induced Diabetic Nephropathy
Tozcu, Duygu
Ozer, Cigdem
Babul, Aydan
Ercan, Sevim
Dilekoz, Ergin
Kaplanoglu, Gulnur Take
Goktas, Guleser
GAZI MEDICAL JOURNAL, 2025, 36 (01): : 96 - 104
[8] Rodent models of streptozotocin-induced diabetic nephropathy
Tesch, Greg H.
Allen, Terri J.
NEPHROLOGY, 2007, 12 (03) : 261 - 266
[9] Pterostilbene Ameliorates Nephropathy Injury in Streptozotocin-Induced Diabetic Rats
Zhang, Ying
Ren, Shaoyu
Ji, Ying
Liang, Yafeng
PHARMACOLOGY, 2019, 104 (1-2) : 71 - 80
[10] Protective effects of allicin on streptozotocin-induced diabetic nephropathy in rats
Huang, Hong
Jiang, Ying
Mao, Genxiang
Yuan, Fang
Zheng, Hexin
Ruan, Yuan
Wu, Tianfeng
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2017, 97 (04) : 1359 - 1366

← 1 2 3 4 5 →