RETRACTED: Resveratrol reverts Streptozotocin-induced diabetic nephropathy (Retracted article. See vol. 47, 2025)

被引：18
作者：
Zhu, Huiping [1 ,2 ]
Zhong, Sen [1 ,2 ]
Yan, Haihong [1 ,2 ]
Wang, Kangyao [1 ,2 ]
Chen, Lingwei [1 ,2 ]
Zhou, Min [1 ,2 ]
Li, Yunsheng [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Peoples Hosp Wenling 1, Dept Nephrol, 333 Chuanan Rd, Wenling 317500, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Wenling Hosp, 333 Chuanan Rd, Wenling 317500, Zhejiang, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2020年 / 25卷
关键词：
Resveratrol; Renal dysfunction; Diabetic nephropathy; mTOR/ULK1; pathway; Autophagy; RENAL LIPID-METABOLISM; PODOCYTE FUNCTION; AUTOPHAGY; MICE; ACCUMULATION; PROGRESSION; PROTECTS; FIBROSIS; TARGET; MTOR;
D O I：
10.2741/4829
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetes causes diabetic nephropathy (DN) which is associated with increased morbidity and mortality in diabetic patients. We tested whether Resveratrol (Res) reverses the systemic effect of Streptozotocin (STZ) induced diabetes and DN. Res treatment opposed the effect of STZ on kidney weight, 24 h urinary albumin excretion, blood urea nitrogen (BUN) and serum creatinine (Scr). Res also decreased DN induced mTOR/ULK1-mediated autophagy and apoptosis and significantly reduced STZ mediated lipid deposition in nephrons, likely by decreasing the levels of lipogenic related proteins (SREBP-1c, ACS) and increased lipidolysis related proteins (PPAR alpha, CPT-1). Together, these findings show the potential of Res in prevention of diabetic nephropathy.
引用
收藏
页码：699 / 709
页数：11
相关论文
共 31 条
[1]   Protective effect of herbomineral formulation (Dolabi) on early diabetic nephropathy in streptozotocin-induced diabetic rats [J].
Baig, Mirza A. ;
Gawali, Vikas B. ;
Patil, Rajesh R. ;
Naik, Suresh R. .
JOURNAL OF NATURAL MEDICINES, 2012, 66 (03) :500-509
[2]   SiRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy [J].
Chan, Edmond Y. W. ;
Kir, Serkan ;
Tooze, Sharon A. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (35) :25464-25474
[3]   US Renal Data System 2011 Annual Data Report [J].
Collins, Allan J. ;
Foley, Robert N. ;
Chavers, Blanche ;
Gilbertson, David ;
Herzog, Charles ;
Johansen, Kirsten ;
Kasiske, Bertram ;
Kutner, Nancy ;
Liu, Jiannong ;
St Peter, Wendy ;
Guo, Haifeng ;
Gustafson, Sally ;
Heubner, Brooke ;
Lamb, Kenneth ;
Li, Shuling ;
Li, Suying ;
Peng, Yi ;
Qiu, Yang ;
Roberts, Tricia ;
Skeans, Melissa ;
Snyder, Jon ;
Solid, Craig ;
Thompson, Bryn ;
Wang, Changchun ;
Weinhandl, Eric ;
Zaun, David ;
Arko, Cheryl ;
Chen, Shu-Cheng ;
Daniels, Frank ;
Ebben, James ;
Frazier, Eric ;
Hanzlik, Christopher ;
Johnson, Roger ;
Sheets, Daniel ;
Wang, Xinyue ;
Forrest, Beth ;
Constantini, Edward ;
Everson, Susan ;
Eggers, Paul ;
Agodoa, Lawrence .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2012, 59 (01) :EVII-E418
[4]   Autophagy in renal diseases [J].
De Rechter, Stephanie ;
Decuypere, Jean-Paul ;
Ivanova, Ekaterina ;
van den Heuvel, Lambertus P. ;
De Smedt, Humbert ;
Levtchenko, Elena ;
Mekahli, Djalila .
PEDIATRIC NEPHROLOGY, 2016, 31 (05) :737-752
[5]   BHBA Influences Bovine Hepatic Lipid Metabolism via AMPK Signaling Pathway [J].
Deng, Qinghua ;
Liu, Guowen ;
Liu, Lei ;
Zhang, Yuming ;
Yin, Liheng ;
Shi, Xiaoxia ;
Wang, Jianguo ;
Yuan, Xue ;
Sun, Guoquan ;
Li, Yu ;
Yang, Wei ;
Guo, Lihui ;
Zhang, Renhe ;
Wang, Zhe ;
Li, Xiaobing ;
Li, Xinwei .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2015, 116 (06) :1070-1079
[6]   Advance of autophagy in chronic kidney diseases [J].
Deng, Xu ;
Xie, Yifan ;
Zhang, Aihua .
RENAL FAILURE, 2017, 39 (01) :306-313
[7]   PPAR-α effects on the heart and other vascular tissues [J].
Francis, GA ;
Annicotte, JS ;
Auwerx, J .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 285 (01) :H1-H9
[8]   ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy [J].
Ganley, Ian G. ;
Lam, Du H. ;
Wang, Junru ;
Ding, Xiaojun ;
Chen, She ;
Jiang, Xuejun .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (18) :12297-12305
[9]   Role of mTOR in podocyte function and diabetic nephropathy in humans and mice [J].
Goedel, Markus ;
Hartleben, Bjoern ;
Herbach, Nadja ;
Liu, Shuya ;
Zschiedrich, Stefan ;
Lu, Shun ;
Debreczeni-Mor, Andrea ;
Lindenmeyer, Maja T. ;
Rastaldi, Maria-Pia ;
Hartleben, Goetz ;
Wiech, Thorsten ;
Fornoni, Alessia ;
Nelson, Robert G. ;
Kretzler, Matthias ;
Wanke, Ruediger ;
Pavenstaedt, Hermann ;
Kerjaschki, Dontscho ;
Cohen, Clemens D. ;
Hall, Michael N. ;
Rueegg, Markus A. ;
Inoki, Ken ;
Walz, Gerd ;
Huber, Tobias B. .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) :2197-2209
[10]   Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy [J].
Herman-Edelstein, Michal ;
Scherzer, Pnina ;
Tobar, Ana ;
Levi, Moshe ;
Gafter, Uzi .
JOURNAL OF LIPID RESEARCH, 2014, 55 (03) :561-572
1234