PEGylate porphyrin-gold nanoparticles conjugates as removable pH-sensor nano-probes for acidic environments

被引：18

作者：

Mineo, Placido G. ^{[1
,2
,3
,4
]}

Abbadessa, Antonio ^{[1
]}

Rescifina, Antonio ^{[5
]}

Mazzaglia, Antonino ^{[6
]}

Nicosia, Angelo ^{[1
]}

Scamporrino, Andrea A. ^{[1
]}

机构：

[1] Univ Catania, Dipartimento Sci Chim, Viale A Doria 6, I-95125 Catania, Italy

[2] CNR, IPCB, Via P Gaifami 18, I-95126 Catania, Italy

[3] CNR, IPCF, Viale F Stagno Alcontres 37, I-98158 Messina, Italy

[4] INSTM Consorzio Interuniv Nazl Sci & Tecnol Mat U, Viale A Doria 6, I-95125 Catania, Italy

[5] Univ Catania, Dipartimento Sci Farm, Viale A Doria 6, I-95125 Catania, Italy

[6] Univ Messina, Dip Sci Chim Biol Farmaceut & Ambientali, CNR, ISMN, Viale F Stagno Alcontres 31, I-98166 Messina, Italy

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2018年 / 546卷

关键词：

Nano-sensors; Gold nanoparticles; Porphyrin; pH-sensor; TD-DFT calculations; POLYDISPERSE POLYMERS; MOLECULAR-WEIGHT; SILICA SURFACES; STAR POLYMERS; FREE-BASE; MONOLAYER; TIME; MASS; BEHAVIOR; METER;

D O I：

10.1016/j.colsurfa.2018.02.061

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hybrid gold nanoparticles covalently coated with 5,10,15-p-(omega-methoxy polyethyleneoxyphenyl)-20-p-(hydroxyphenyl) porphyrin molecules, having about 16 repetitive units in each of its poly(oxyethylene) branches, were synthesized and characterized by UV-vis, fluorescence, dynamic light scattering (DLS), transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) measurements. Their [H3O+] optical sensing behavior was also studied and compared to that of the similar water-soluble star polymer 5,10,15,20-tetrakis p-[omega-methoxypoly(ethyleneoxy)] phenylporphyrin. Changing the pH of a solution, the UV-vis spectra of the PEGylate porphyrin gold nanoparticles conjugates showed the gradual disappearance of the Soret band at 424 nm and the progressive increase of a new band at 451 nm. Upon acidic titration, also the fluorescence spectra showed a gradual disappearing of the fluorescence at 654 nm. Moreover, an unusual B-Band red-shift and a decreasing of porphyrin core basicity were observed for this porphyrin bonded to the gold nanoparticle surfaces. To rationalize these phenomena an in silico TD-DFT calculation study was then conducted. For its properties, this new system: can be used in both aqueous and organic media; by a simple treatment of the solution at 80 degrees C under N-2 gas stream the starting Soret signals can be recovered; the nanoparticles can be eventually removed from the solution by centrifugation.

引用

页码：40 / 47

页数：8