Effects of interleukin-37 on cardiac function after myocardial infarction in mice

被引:3
作者
Xu, Daoying [1 ]
Wang, Aiqin [2 ]
Jiang, Fengqin [1 ]
Hu, Junhong [1 ]
Zhang, Xiuzhou [1 ]
机构
[1] Binzhou Peoples Hosp, Dept Cardiol, Binzhou City 256610, Shandong, Peoples R China
[2] Binzhou Peoples Hosp, Dept Crit Care Med, Binzhou City 256610, Shandong, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 05期
关键词
Interleukin-37; myocardial infarction; cardiac function; inflammation; NF-KAPPA-B; INFLAMMATION; IL-37; DYSFUNCTION; INHIBITION; SUPPRESSES; PATHWAYS; PROTECTS; HEART; IL-18;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Interleukin-37 (IL-37) is a new discovered member of the interleukin family and plays anti-inflammatory effect in some inflammatory disease. A recent study found that IL-37 elevated significantly in peripheral blood of patients with acute myocardial infarction. We aimed to explore the effect IL-37 on cardiac function after mice myocardial infarction (MI) and its mechanism. Methods: Acute MI mouse model was established and divided into three groups: sham group, MI group and IL-37 treatment group. MPO expression was detected by immunohistochemistry; NF-kappa B signaling pathway was tested by Western blot; and cardiac function was measured by echocardiography. Results: Compared with MI mice, IL-37 treatment showed an obvious decrease of MPO expression, suppression of p-p65 expression, and improved cardiac function by decreasing left ventricular shortening fraction (LVFS). Conclusion: IL-37 may improve MI mice cardiac function via inhibition of inflammatory NF-kappa B signaling pathway.
引用
收藏
页码:5247 / 5251
页数:5
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