Obesity as a risk factor in COVID-19: Possible mechanisms and implications

被引：35

作者：

Petrova, Dafina ^{[1
,2
,3
]}

Salamanca-Fernandez, Elena ^{[1
,2
,3
]}

Rodriguez Barranco, Miguel ^{[1
,2
,3
]}

Navarro Perez, Pilar ^{[1
]}

Jimenez Moleon, Jose Juan ^{[2
,3
,4
]}

Sanchez, Maria-Jose ^{[1
,2
,3
,4
]}

机构：

[1] Escuela Andaluza Salud Publ EASP, Granada, Spain

[2] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain

[3] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain

[4] Univ Granada, Dept Med Prevent & Salud Publ, Granada, Spain

来源：

ATENCION PRIMARIA | 2020年 / 52卷 / 07期

关键词：

COVID-19; SARS-CoV-2; Pandemic; Obesity; Overweight;

D O I：

10.1016/j.aprim.2020.05.003

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recent reports suggest that obesity is a risk factor for more severe coronavirus disease. This article summarizes the available scientific evidence on the rote of obesity in COVID-19. We focus on implications for younger patients and the proposed biological mechanisms that could explain both the higher risk observed and the possible higher contagiousness of people with obesity. We consider implications of the pandemic for people with obesity in relation to: difficulties in managing hospitalized patients, implications of confinement for the control and treatment of obesity, and the stigma people with obesity suffer, that could increase should the relationship between obesity and COVID-19 be confirmed. Understanding the role of obesity in COVID-19 should be a public health priority, given the high prevalence of this condition in our country. (C) 2020 The Authors. Published by Elsevier Espana, S.L.U.

引用

页码：496 / 500

页数：5

共 28 条

[1] Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions [J].

Bouillon, Roger ;

Marcocci, Claudio ;

Carmeliet, Geert ;

Bikle, Daniel ;

White, John H. ;

Dawson-Hughes, Bess ;

Lips, Paul ;

Munns, Craig F. ;

Lazaretti-Castro, Marise ;

Giustina, Andrea ;

Bilezikian, John .

ENDOCRINE REVIEWS, 2019, 40 (04) :1109-1151

[2] Obesity is Associated with Severe Forms of COVID-19 [J].

Caussy, Cyrielle ;

Wallet, Florent ;

Laville, Martine ;

Disse, Emmanuel .

OBESITY, 2020, 28 (07) :1175-1175

[3] Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents [J].

Di Angelantonio, Emanuele ;

Bhupathiraju, Shilpa N. ;

Wormser, David ;

Gao, Pei ;

Kaptoge, Stephen ;

de Gonzalez, Amy Berrington ;

Cairns, Benjamin J. ;

Huxley, Rachel ;

Jackson, Chandra L. ;

Joshy, Grace ;

Lewington, Sarah ;

Manson, JoAnn E. ;

Murphy, Neil ;

Patel, Alpa V. ;

Samet, Jonathan M. ;

Woodward, Mark ;

Zheng, Wei ;

Zhou, Maigen ;

Bansal, Narinder ;

Barricarte, Aurelio ;

Carter, Brian ;

Cerhan, James R. ;

Collins, Rory ;

Smith, George Davey ;

Fang, Xianghua ;

Franco, Oscar H. ;

Green, Jane ;

Halsey, Jim ;

Hildebrand, Janet S. ;

Jung, Keum Ji ;

Korda, Rosemary J. ;

McLerran, Dale F. ;

Moore, Steven C. ;

O'Keeff, Linda M. ;

Paige, Ellie ;

Ramond, Anna ;

Reeves, Gillian K. ;

Rolland, Betsy ;

Sacerdote, Carlotta ;

Sattar, Naveed ;

Sofianopoulou, Eleni ;

Stevens, June ;

Thun, Michael ;

Ueshima, Hirotsugu ;

Yang, Ling ;

Yun, Young Duk ;

Willeit, Peter ;

Banks, Emily ;

Beral, Valerie ;

Chen, Zhengming .

LANCET, 2016, 388 (10046) :776-786

[4]

Docherty AB, 2020, ISARIC4C INVESTIGATO, DOI [10:1101/2020.04.23.20076047, DOI 10.1101/2020.04.23.20076047]

[5]

Fallon K, 2020, AUS J GEN PRAC, DOI [10.31128/AJGP-COVID-13, DOI 10.31128/AJGP-C0VID-13]

[6] Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019-COVID-NET, 14 States, March 1-30, 2020 [J].

Garg, Shikha ;

Kim, Lindsay ;

Whitaker, Michael ;

O'Halloran, Alissa ;

Cummings, Charisse ;

Holstein, Rachel ;

Prill, Mila ;

Chai, Shua J. ;

Kirley, Pam D. ;

Alden, Nisha B. ;

Kawasaki, Breanna ;

Yousey-Hindes, Kimberly ;

Niccolai, Linda ;

Anderson, Evan J. ;

Openo, Kyle P. ;

Weigel, Andrew ;

Monroe, Maya L. ;

Ryan, Patricia ;

Henderson, Justin ;

Kim, Sue ;

Como-Sabetti, Kathy ;

Lynfield, Ruth ;

Sosin, Daniel ;

Torres, Salina ;

Muse, Alison ;

Bennett, Nancy M. ;

Billing, Laurie ;

Sutton, Melissa ;

West, Nicole ;

Schaffner, William ;

Talbot, H. Keipp ;

Aquino, Clarissa ;

George, Andrea ;

Budd, Alicia ;

Brammer, Lynnette ;

Langley, Gayle ;

Hall, Aron J. ;

Fry, Alicia .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2020, 69 (15) :458-464

[7]

Ghelichkhani P, 2020, ARCH ACAD EMERG MED, V8

[8] Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths [J].

Grant, William B. ;

Lahore, Henry ;

McDonnell, Sharon L. ;

Baggerly, Carole A. ;

French, Christine B. ;

Aliano, Jennifer L. ;

Bhattoa, Harjit P. .

NUTRIENTS, 2020, 12 (04)

[9] Clinical aspects and cytokine response in severe H1N1 influenza A virus infection [J].

Hagau, Natalia ;

Slavcovici, Adriana ;

Gonganau, Daniel N. ;

Oltean, Simona ;

Dirzu, Dan S. ;

Brezoszki, Erika S. ;

Maxim, Mihaela ;

Ciuce, Constantin ;

Mlesnite, Monica ;

Gavrus, Rodica L. ;

Laslo, Carmen ;

Hagau, Radu ;

Petrescu, Magda ;

Studnicska, Daniela M. .

CRITICAL CARE, 2010, 14 (06)

[10] A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) [J].

Jin, Ying-Hui ;

Cai, Lin ;

Cheng, Zhen-Shun ;

Cheng, Hong ;

Deng, Tong ;

Fan, Yi-Pin ;

Fang, Cheng ;

Huang, Di ;

Huang, Lu-Qi ;

Huang, Qiao ;

Han, Yong ;

Hu, Bo ;

Hu, Fen ;

Li, Bing-Hui ;

Li, Yi-Rong ;

Liang, Ke ;

Lin, Li-Kai ;

Luo, Li-Sha ;

Ma, Jing ;

Ma, Lin-Lu ;

Peng, Zhi-Yong ;

Pan, Yun-Bao ;

Pan, Zhen-Yu ;

Ren, Xue-Qun ;

Sun, Hui-Min ;

Wang, Ying ;

Wang, Yun-Yun ;

Weng, Hong ;

Wei, Chao-Jie ;

Wu, Dong-Fang ;

Xia, Jian ;

Xiong, Yong ;

Xu, Hai-Bo ;

Yao, Xiao-Mei ;

Yuan, Yu-Feng ;

Ye, Tai-Sheng ;

Zhang, Xiao-Chun ;

Zhang, Ying-Wen ;

Zhang, Yin-Gao ;

Zhang, Hua-Min ;

Zhao, Yan ;

Zhao, Ming-Juan ;

Zi, Hao ;

Zeng, Xian-Tao ;

Wang, Yong-Yan ;

Wang, Xing-Huan .

MILITARY MEDICAL RESEARCH, 2020, 7 (01)

← 1 2 3 →