Nocardiopsins C and D and nocardiopyrone A: new polyketides from an Australian marine-derived Nocardiopsis sp.

被引：19

作者：

Raju, Ritesh ^{[1
]}

Piggott, Andrew M. ^{[1
]}

Quezada, Michelle ^{[1
]}

Capon, Robert J. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

来源：

TETRAHEDRON | 2013年 / 69卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

Nocardiopsis; Marine-derived actinomycetes; Prolinyl-macrolactam polyketides; alpha-Pyrone polyketides; Microbial natural products chemistry; RAPAMYCIN ANALOGS; STARTER UNIT; ACTINOMYCETE; SYNTHASE; GERMICIDIN; ACP;

D O I：

10.1016/j.tet.2012.10.104

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Nocardiopsis sp. (CMB-M0232) recovered from marine sediment collected off the coast of South Molle Island, Queensland, Australia, yielded two new examples of rare prolinyl-macrolactam polyketides, nocardiopsins C (1) and D (2), a new highly substituted alpha-pyrone polyketide, nocardiopyrone A (3), and the previously reported macrolide polyketides nocardiopsins A (4) and B (5). Structures were assigned on the basis of detailed spectroscopic analysis, degradation, and chemical derivatization. PCR amplification of CMB-M0232 genomic DNA revealed the presence of type I and type II polyketide synthase and non-ribosomal peptide synthase domains. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：692 / 698

页数：7

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