Reference values for serum levels of insulin-like growth factor 1 (IGF-1) and IGF-binding protein 3 (IGFBP-3) in the West Black Sea region of Turkey

被引：23
作者：
Guven, Berrak [1 ]
Can, Murat [1 ]
Mungan, Gorkem [1 ]
Acikgoz, Serefden [1 ]
机构：
[1] Bulent Ecevit Univ Med, Dept Biochem, Fac Med, Zonguldak, Turkey
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2013年 / 73卷 / 02期
关键词：
Insulin-like growth factor 1; Insulin-like growth factor binding protein 3; reference values; adult; children; FACTOR-I; REFERENCE RANGES; HORMONE-SECRETION; CLINICAL UTILITY; OBESE SUBJECTS; CHILDREN; PUBERTY; CHILDHOOD; SYSTEM;
D O I：
10.3109/00365513.2012.755739
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objectives. The aim of this study was to determine the normal values of serum IGF-1 and IGFBP-3 in Turkish children and adults (1-79 years). Material and methods. The study included 571 healthy children and 625 healthy adults from the West Black Sea region of Turkey. Serum IGF-1 and IGFBP-3 concentrations were determined using a chemiluminescent immunometric assay on an Immulite 1000 analyzer. Results. IGF-1 and IGFBP-3 levels tended to be higher in girls compared to boys among the children. The differences were statistically significant in puberty from age 12-14 years for IGF-1 and prepubertally from age 9-10 years for IGFBP-3. Peaks of serum IGF-1 levels were observed 2 years earlier in girls (14 years) than boys (16 years). The general pattern of IGFBP-3 was similar to IGF-1 during puberty. In adults, IGF-1 and IGFBP-3 levels decreased by age. There was no significant difference in IGF-1 and IGFBP3 values between men and women in any age group. Conclusions. This study established age-and sex-specific reference values for serum IGF-1 and IGFBP-3 in healthy Turkish children and adults.
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收藏
页码：135 / 140
页数：6
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