Nylon-3 Polymers with Selective Antifungal Activity

被引：122

作者：

Liu, Runhui ^{[1
,2
]}

Chen, Xinyu ^{[1
]}

Hayouka, Zvi ^{[1
]}

Chakraborty, Saswata ^{[1
]}

Falk, Shaun P. ^{[3
]}

Weisblum, Bernard ^{[3
]}

Masters, Kristyn S. ^{[2
]}

Gellman, Samuel H. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Med, Madison, WI 53706 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 14期

关键词：

HOST-DEFENSE PEPTIDES; DE-NOVO DESIGN; ANTIMICROBIAL BETA-PEPTIDES; RING-OPENING POLYMERIZATION; ANIONIC-POLYMERIZATION; ANTIBACTERIAL ACTIVITY; HEMOLYTIC ACTIVITIES; RANDOM COPOLYMERS; PEPTOID MIMICS; LYTIC PEPTIDES;

D O I：

10.1021/ja4006404

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Host-defense peptides inhibit bacterial growth but show little toxicity toward mammalian cells. A variety of synthetic polymers have been reported to mimic this antibacterial selectivity; however, achieving comparable selectivity for fungi is more difficult because these pathogens are eukaryotes. Here we report nylon-3 polymers based on a novel subunit that display potent antifungal activity (MIC = 3.1 mu g/mL for Candida albicans) and favorable selectivity (IC10 > 400 mu g/mL for 3T3 fibroblast toxicity; HC10 > 400 mu g/mL for hemolysis).

引用

页码：5270 / 5273

页数：4

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