Resistance to β-lactams in enterococci

被引：42

作者：

Gagetti, Paula ^{[1
,2
]}

Bonofiglio, Laura ^{[1
,3
]}

Garcia Gabarrot, Gabriela ^{[1
,4
]}

Kaufman, Sara ^{[1
,5
]}

Mollerach, Marta ^{[1
,2
]}

Vigliarolo, Laura ^{[1
,6
]}

von Specht, Martha ^{[1
,7
,8
]}

Toresani, Ines ^{[1
,9
]}

Lopardo, Horacio A. ^{[1
,6
]}

机构：

[1] Soc Argentina Bacteriol Micol & Parasitol Clin SA, Grp STREP, Div Asociac Argentina Microbiol, Buenos Aires, DF, Argentina

[2] ANLIS Dr Carlos G Malbran, Serv Antimicrobianos, Dept Bacteriol, INEI, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Catedra Microbiol, Fac Farm & Bioquim, Dept Microbiol Inmunol & Biotecnol, Buenos Aires, DF, Argentina

[4] Univ Republica, Programa Desarrollo Ciencias Basicas PEDECIBA, Montevideo, Uruguay

[5] Hosp Juan A Fernandez, Div Lab, Secc Microbiol Clin, Buenos Aires, DF, Argentina

[6] Univ Nacl La Plata, Catedra Microbiol Clin, Fac Ciencias Exactas, La Plata, Buenos Aires, Argentina

[7] Hosp Dr Fernando Barreyro, Lab Bacteriol, Posadas, Misiones, Argentina

[8] Univ Nacl Misiones, Fac Ciencias Exactas Quim & Nat, Dept Microbiol, Posadas, Provincia De Mi, Argentina

[9] Univ Nacl Rosario, Fac Ciencias Bioquim, Catedra Bacteriol, Rosario, Santa Fe, Argentina

来源：

REVISTA ARGENTINA DE MICROBIOLOGIA | 2019年 / 51卷 / 02期

关键词：

Enterococci; Enterococcus faecalis; Enterococcus faecium; beta-Lactams; Antimicrobial resistance; AMPICILLIN PLUS CEFTRIAXONE; PENICILLIN-RESISTANT; IN-VITRO; EXPERIMENTAL ENDOCARDITIS; GENTAMICIN-RESISTANT; FAECALIS; SPREAD; SUSCEPTIBILITY; AMOXICILLIN; EFFICACY;

D O I：

10.1016/j.ram.2018.01.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enterococci are intrinsically resistant to several antimicrobial classes and show a great ability to acquire new mechanisms of resistance. Resistance to beta-lactam antibiotics is a major concern because these drugs either alone or in combination are commonly used for the treatment of enterococcal infections. Ampicillin resistance, which is rare in Enterococcus faecalis, occurs in most of the hospital-associated Enterococcus faecium isolates. High-level resistance to ampicillin in E. faecium is mainly due to the enhanced production of PBP5 and/or by polymorphisms in the beta subunit of this protein. The dissemination of high-level ampicillin resistance can be the result of both clonal spread of strains with mutated pbp5 genes and horizontal gene transfer. (C) 2018 Asociacion Argentina de Microbiologia. Published by Elsevier Espana, S.L.U.

引用

页码：179 / 183

页数：5

共 30 条

[1] Management of multidrug-resistant enterococcal infections [J].

Arias, C. A. ;

Contreras, G. A. ;

Murray, B. E. .

CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 (06) :555-562

[2] The rise of the Enterococcus: beyond vancomycin resistance [J].

Arias, Cesar A. ;

Murray, Barbara E. .

NATURE REVIEWS MICROBIOLOGY, 2012, 10 (04) :266-278

[3] Actividad in vitro de ampicilina-ceftriaxona frente a aislamientos de Enterococcus faecalis recuperados de infecciones invasivas [J].

Burguer Moreira, Noelia ;

Nastro, Marcela ;

Vay, Carlos ;

Famiglietti, Angela ;

Hernan Rodriguez, Carlos .

REVISTA ARGENTINA DE MICROBIOLOGIA, 2016, 48 (01) :57-61

[4] Enterococcus: phenotype and genotype resistence and epidemiology in Spain [J].

Cercenado, Emilia .

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2011, 29 :59-65

[5] Penicillin-resistant, ampicillin-susceptible Enterococcus faecalis of hospital origin: pbp4 gene polymorphism and genetic diversity [J].

Conceicao, Natalia ;

Pinheiro da Silva, Lucas Emanuel ;

da Costa Darini, Ana Lucia ;

Pitondo-Silva, Andre ;

de Oliveira, Adriana Goncalves .

INFECTION GENETICS AND EVOLUTION, 2014, 28 :289-295

[6] Ampicillin Susceptibility Can Predict In Vitro Susceptibility of Penicillin-Resistant, Ampicillin-Susceptible Enterococcus faecalis Isolates to Amoxicillin but Not to Imipenem and Piperacillin [J].

Conceicao, Natalia ;

Hueb Barata de Oliveira, Cristina da Cunha ;

Pinheiro da Silva, Lucas Emanuel ;

Cardoso de Souza, Lais Rezende ;

de Oliveira, Adriana Goncalves .

JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (11) :3729-3731

[7] Ampicillin Plus Ceftriaxone Is as Effective as Ampicillin Plus Gentamicin for Treating Enterococcus faecalis Infective Endocarditis [J].

Fernandez-Hidalgo, Nuria ;

Almirante, Benito ;

Gavalda, Joan ;

Gurgui, Merce ;

Pena, Carmen ;

de Alarcon, Aristides ;

Ruiz, Josefa ;

Vilacosta, Isidre ;

Montejo, Miguel ;

Vallejo, Nuria ;

Lopez-Medrano, Francisco ;

Plata, Antonio ;

Lopez, Javier ;

Hidalgo-Tenorio, Carmen ;

Galvez, Juan ;

Saez, Carmen ;

Manuel Lomas, Jose ;

Falcone, Marco ;

de la Torre, Javier ;

Martinez-Lacasa, Xavier ;

Pahissa, Albert .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (09) :1261-1268

[8] OVERPRODUCTION OF A LOW-AFFINITY PENICILLIN-BINDING PROTEIN AND HIGH-LEVEL AMPICILLIN RESISTANCE IN ENTEROCOCCUS-FAECIUM [J].

FONTANA, R ;

ALDEGHERI, M ;

LIGOZZI, M ;

LOPEZ, H ;

SUCARI, A ;

SATTA, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (09) :1980-1983

[9] Analysis of PBP5 of Early US Isolates of Enterococcus faecium: Sequence Variation Alone Does Not Explain Increasing Ampicillin Resistance over Time [J].

Galloway-Pena, Jessica R. ;

Rice, Louis B. ;

Murray, Barbara E. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (07) :3272-3277

[10] Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides [J].

Gavaldà, J ;

Torres, C ;

Tenorio, C ;

López, P ;

Zaragoza, M ;

Capdevila, JA ;

Almirante, B ;

Ruiz, F ;

Borrell, N ;

Gomis, X ;

Pigrau, C ;

Baquero, F ;

Pahissa, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (03) :639-646

← 1 2 3 →