Preeclampsia: a link between trophoblast dysregulation and an antiangiogenic state

被引：96

作者：

Romero, Roberto ^{[1
,2
]}

Chaiworapongsa, Tinnakorn ^{[1
,2
,3
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD USA

[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Dept Hlth & Human Serv, Detroit, MI USA

[3] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 07期

基金：

美国国家卫生研究院;

关键词：

ELEVATED LIVER-ENZYMES; HUMAN CYTOTROPHOBLASTS; CLINICAL-SIGNIFICANCE; ANGIOGENIC FACTORS; NATURAL-HISTORY; HYPERTENSION; RISK; HEMOLYSIS; PATHOPHYSIOLOGY; PHENOTYPE;

D O I：

10.1172/JCI70431

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A 24-year-old nulliparous woman developed mildly elevated blood pressure (140-150/90-100 mmHg) without proteinuria (20 mg protein in a 24-hour urine collection) at 30(6/7) weeks of gestation. The fetus was small for gestational age (estimated fetal weight under the fifth percentile). At 32(5/7) weeks of gestation, the patient complained of epigastric pain, blood pressure was 180/110 mmHg, proteinuria was documented (780 mg protein in a 24-hour urine collection), schistocytes were detected in the peripheral smear, platelet count was 60,000 cells per mm(3), and serum glutamic oxaloacetic transaminase was 234 U/1. The patient was diagnosed with severe preeclampsia/HELLP syndrome. Antenatal steroids were administered to induce fetal lung maturity. She and her family want to know the causes of this condition, what treatment is available, and whether there are any longterm implications of this diagnosis.

引用

页码：2775 / 2777

页数：3

共 47 条

[1] New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications [J].