Mechanisms of Mediator complex action in transcriptional activation

被引：81

作者：

Ansari, Suraiya A. ^{[1
]}

Morse, Randall H. ^{[1
,2
]}

机构：

[1] New York State Dept Hlth, Wadsworth Ctr, Mol Genet Lab, Albany, NY 12201 USA

[2] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 15期

基金：

美国国家科学基金会;

关键词：

Transcription; Mediator; Co-activator; SAGA; Swi/Snf; RNA-POLYMERASE-II; IN-VIVO TARGET; TERMINAL REPEAT DOMAIN; TATA-BINDING PROTEIN; YEAST MEDIATOR; SRB MEDIATOR; SACCHAROMYCES-CEREVISIAE; INDEPENDENT RECRUITMENT; DEPENDENT TRANSCRIPTION; COACTIVATOR COMPLEX;

D O I：

10.1007/s00018-013-1265-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mediator is a large multisubunit complex that plays a central role in the regulation of RNA Pol II transcribed genes. Conserved in overall structure and function among eukaryotes, Mediator comprises 25-30 protein subunits that reside in four distinct modules, termed head, middle, tail, and CDK8/kinase. Different subunits of Mediator contact other transcriptional regulators including activators, co-activators, general transcription factors, subunits of RNA Pol II, and specifically modified histones, leading to the regulated expression of target genes. This review is focused on the interactions of specific Mediator subunits with diverse transcription regulators and how those interactions contribute to Mediator function in transcriptional activation.

引用

页码：2743 / 2756

页数：14

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