Recent Progress on the Applications of Nanozyme in Surface-Enhanced Raman Scattering

Nanozymes are nanomaterial with natural enzyme-like activity and can catalyze specific reactions for analyte identification and detection. Compared to natural enzymes, they have several benefits, including being steady, low-cost, easy to prepare and store. Based on the promising development of nanozymes in surface-enhanced Raman scattering (SERS), this paper reviews the classification of different types of nanozymes in SERS, including metal-based nanozyme, carbon-based nanozyme, metal-organic framework (MOF)/covalent organic framework (COF)-based nanozyme, and semiconductor-based nanozyme, followed by a detailed overview of their SERS applications in disease diagnosis, food safety, and environmental safety. Finally, this paper discusses the practical shortcomings of nanozymes in SERS applications and makes some suggestions for further research.