Secoiridoid glycosides from the fruits ofCornus officinalis

被引：5
作者：
Wang, Xin [1 ]
Zhong, Xiang-Jian [1 ]
Zhou, Na [1 ]
Ji, Lin-Lin [1 ]
Li, Jin-Jie [1 ]
Cai, Ning [1 ]
Wang, Qing-Bo [2 ]
Lin, Peng-Cheng [2 ]
Shang, Xiao-Ya [1 ]
机构：
[1] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China
[2] Qinghai Univ Nationalities, Qinghai Prov Key Lab Phytochem Tibetan Plateu, Xining, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 09期
关键词：
Cornus officinalis; secoiridoid glycosides; neuroprotective activity; IRIDOID GLYCOSIDES;
D O I：
10.1080/14786419.2020.1834547
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Five new secoiridoid glycosides, cornusphenosides E-I (1-5), were isolated and characterized from an active fraction of ethanol extract of the fruits ofCornus officinalis. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound5(when evaluated at 10 mu M) showed the neuroprotective effect against H2O2-induced SH-SY5Y cell damage.
引用
收藏
页码：2329 / 2335
页数：7
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