Convenient and Eco-Friendly Method for the Conversion of Benzylic Alcohols into Aldehydes, Ketones, and Carboxylic Acids Using NaOCl without any Additives in 1,2-Dimethoxyethane

被引：10

作者：

Fukuda, Naohiro ^{[1
]}

Kajiwara, Takeshi ^{[1
]}

Katou, Tomoaki ^{[1
]}

Majima, Keisuke ^{[1
]}

Ikemoto, Tomomi ^{[1
]}

机构：

[1] Takeda Pharmaceut Co Ltd, Chem Dev Labs, CMC Ctr, Yodogawa Ku, Osaka 5328686, Japan

来源：

SYNLETT | 2013年 / 24卷 / 11期

关键词：

NaOCl; 1,2-dimethoxyethane; oxidation; alcohol; carbonyl compound;

D O I：

10.1055/s-0033-1338856

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of benzylic alcohols to aldehydes, ketones, and carboxylic acids using NaOCl in 1,2-dimethoxyethane without any additives has been developed. 4-Methylbenzyl alcohol and diphenyl methanol were converted into the corresponding aldehyde and ketone in 97% and 92% yield, respectively. Furthermore, 4-nitrobenzyl alcohol was directly converted into the corresponding carboxylic acid in 99% yield.

引用

页码：1438 / 1442

页数：5