Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

被引：2785

作者：

Yang, Wanjuan ^{[1
]}

Soares, Jorge ^{[1
]}

Greninger, Patricia ^{[2
]}

Edelman, Elena J. ^{[2
]}

Lightfoot, Howard ^{[1
]}

Forbes, Simon ^{[1
]}

Bindal, Nidhi ^{[1
]}

Beare, Dave ^{[1
]}

Smith, James A. ^{[3
]}

Thompson, I. Richard ^{[1
]}

Ramaswamy, Sridhar ^{[2
]}

Futreal, P. Andrew ^{[1
]}

Haber, Daniel A. ^{[2
,4
]}

Stratton, Michael R. ^{[1
]}

Benes, Cyril ^{[2
]}

McDermott, Ultan ^{[1
]}

Garnett, Mathew J. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

[2] Harvard Univ, Massachusetts Gen Hosp, Ctr Mol Therapeut, Canc Ctr,Med Sch, Charlestown, MA 02129 USA

[3] Wellcome Trust Sanger Inst, Core Software Serv, Hinxton CB10 1SA, England

[4] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期

基金：

英国惠康基金;

关键词：

IDENTIFICATION;

D O I：

10.1093/nar/gks1111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database(www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in cancer cells and molecular markers of drug response. Data are freely available without restriction. GDSC currently contains drug sensitivity data for almost 75 000 experiments, describing response to 138 anticancer drugs across almost 700 cancer cell lines. To identify molecular markers of drug response, cell line drug sensitivity data are integrated with large genomic datasets obtained from the Catalogue of Somatic Mutations in Cancer database, including information on somatic mutations in cancer genes, gene amplification and deletion, tissue type and transcriptional data. Analysis of GDSC data is through a web portal focused on identifying molecular biomarkers of drug sensitivity based on queries of specific anticancer drugs or cancer genes. Graphical representations of the data are used throughout with links to related resources and all datasets are fully downloadable. GDSC provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies.

引用

页码：D955 / D961

页数：7

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