Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration

被引：0
|
作者：
Lemarie, Fanny [1 ]
Chang, Chun Wai [1 ]
Blatchford, David R. [1 ]
Amor, Rumelo [1 ]
Norris, Greg [1 ]
Tetley, Laurence [2 ]
McConnell, Gail [1 ]
Dufes, Christine [1 ]
机构：
[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland
[2] Univ Glasgow, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
来源：
NANOMEDICINE | 2013年 / 8卷 / 02期
基金：
英国惠康基金;
关键词：
cancer therapy; epigallocatechin-3-gallate; green tea; transferrin; tumor targeting; TUMOR-REGRESSION; GENE-EXPRESSION; IN-VITRO; CANCER; TRANSFERRIN; DELIVERY; TOCOTRIENOL; LIPOSOMES; CATECHINS; CASPASES;
D O I：
10.2217/NNM.12.83
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: The therapeutic potential of epigallocatechin-3-gallate (EGCG), a green tea polyphenol with anticancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study was to determine whether a tumor-targeted vesicular formulation of EGCG would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. Materials & methods: Transferrin-bearing vesicles encapsulating EGCG were administered intravenously to mice bearing subcutaneous A431 and B16-F10 tumors. Results: The intravenous administration of EGCG encapsulated in transferrin-bearing vesicles resulted in tumor suppression in 40% of A431 and B16-F10 tumors. Animal survival was improved by more than 20 days compared with controls. Conclusion: Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy.
引用
收藏
页码：181 / 192
页数：12
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