PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer?

被引：62

作者：

Ashrafizadeh, Milad ^{[1
]}

Zarrabi, Ali ^{[2
]}

Samarghandian, Saeed ^{[3
]}

Najafi, Masoud ^{[4
]}

机构：

[1] Univ Tabriz, Fac Vet Med, Dept Basic Sci, Tabriz, Iran

[2] Sabanci Univ Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey

[3] Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran

[4] Kermanshah Univ Med Sci, Sch Paramed Sci, Radiol & Nucl Med Dept, Kermanshah, Iran

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2020年 / 881卷

关键词：

Bladder cancer; Phosphatase and tensin homolog (PTEN); PI3K/Akt; Anti-tumor drug; MicroRNAs; LONG NONCODING RNAS; CELL-CYCLE ARREST; NF-KAPPA-B; TUMOR-SUPPRESSOR; COLORECTAL-CANCER; INHIBITS PROLIFERATION; PROMOTES APOPTOSIS; HEALTH ECONOMICS; CIRCULAR RNAS; BREAST-CANCER;

D O I：

10.1016/j.ejphar.2020.173226

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bladder cancer accounts for high morbidity and mortality around the world and its incidence rate is suggested to be higher in following years. A number of factors involve in bladder cancer development such as lifestyle and drugs. However, it appears that genetic factors play a significant role in bladder cancer development and progression. Phosphatase and tensin homolog (PTEN) is a cancer-related transcription factor that is corelated with reduced proliferation and invasion of cancer cells by negatively targeting PI3K/Akt/mTOR signaling pathway. In the present review, we aimed to explore the role of PTEN in bladder cancer cells and how upstream modulators affect PTEN in this life-threatening disorder. Down-regulation of PTEN is associated with poor prognosis, chemoresistance and progression of cancer cells. Besides, microRNAs, long non-coding RNAs, circular RNAs and other molecular pathways such as NF-kB are able to target PTEN in bladder cancer cells. Notably, anti-tumor drugs such as kaempferol, beta-elemene and sorafenib upregulate the expression of PTEN to exert their inhibitory effects on bladder cancer cells.

引用

页数：15

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