Application of diagnostic markers to invasive aspergillosis in children

被引：15

作者：

Roilides, Emmanuel ^{[1
]}

Pana, Zoi-Dorothea ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Hippokrat Gen Hosp, Sch Med, Pediat Dept 3, Thessaloniki 54642, Greece

来源：

ADVANCES AGAINST ASPERGILLOSIS I | 2012年 / 1272卷

关键词：

invasive aspergillosis; beta-1; 3-D-glucan; galactomannan; children; HEMATOPOIETIC STEM-CELL; CHRONIC GRANULOMATOUS-DISEASE; POLYMERASE-CHAIN-REACTION; FUNGAL-INFECTIONS; PULMONARY ASPERGILLOSIS; PCR ASSAY; GALACTOMANNAN ANTIGEN; LABORATORY DIAGNOSIS; PEDIATRIC-PATIENTS; IDENTIFICATION;

D O I：

10.1111/j.1749-6632.2012.06828.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Early mycological detection of Aspergillus species is the cornerstone for a prompt diagnosis, appropriate treatment strategies, and improved survival of patients with invasive aspergillosis (IA), irrespective of age. However, the currently available laboratory tests for the diagnosis of IA include culture with direct microscopy, histology, and antigenic markers, such as galactomannan and beta-1, 3-D-glucan, Aspergillus spp. DNA detection by PCR, and imaging studies, such as high-resolution CT scan. However, all need further validation, especially in children. In this review we focus on the diagnosis of IA emphasizing the current perspectives, difficulties in interpretation, and the need of further evaluation from a pediatric point of view.

引用

页码：1 / 8

页数：8

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