Gut microbiota and metabolic disorders: how prebiotic can work?

被引：120

作者：

Delzenne, Nathalie M. ^{[1
]}

Neyrinck, Audrey M. ^{[1
]}

Cani, Patrice D. ^{[1
]}

机构：

[1] Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, B-1200 Brussels, Belgium

来源：

BRITISH JOURNAL OF NUTRITION | 2013年 / 109卷

关键词：

Gut microbiota; Obesity; Prebiotics; Inflammation; Gut peptides; GLUCAGON-LIKE PEPTIDE-1; HIGH-FAT-DIET; ENERGY-METABOLISM; LIPID-METABOLISM; ADIPOSE-TISSUE; WEIGHT-LOSS; OBESITY; OLIGOFRUCTOSE; INFLAMMATION; MODULATION;

D O I：

10.1017/S0007114512004047

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Experimental data in animals, but also observational studies in obese patients, suggest that the composition of the gut microbiota differs in obese v. lean individuals, in diabetic v. non-diabetic patients or in patients presenting other diseases associated with obesity or nutritional dysbalance, such as non-alcoholic steatohepatitis. In the present review, we will describe how changes in the gut microbiota composition and/or activity by dietary fibres with prebiotic properties, can modulate host gene expression and metabolism. We will evaluate their potential relevance in the management of obesity and related metabolic disturbances, in view of the experimental data and intervention studies published up to date.

引用

页码：S81 / S85

页数：5

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