Mitochondrial sirtuins and metabolic homeostasis

被引：46

作者：

Pirinen, Eija ^{[1
,2
]}

Lo Sasso, Giuseppe ^{[1
]}

Auwerx, Johan ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, Sch Life Sci, CH-1015 Lausanne, Switzerland

[2] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2012年 / 26卷 / 06期

基金：

瑞士国家科学基金会; 芬兰科学院;

关键词：

deacetylase; energy homeostasis; metabolism; mitochondria; sirtuins; FATTY-ACID OXIDATION; SMALL-MOLECULE ACTIVATORS; CALORIE RESTRICTION; SKELETAL-MUSCLE; REGULATES SIRT1; MAMMALIAN SIR2; SACCHAROMYCES-CEREVISIAE; INSULIN SENSITIVITY; DEACETYLASE SIRT3; CELL-SURVIVAL;

D O I：

10.1016/j.beem.2012.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The maintenance of metabolic homeostasis requires the well-orchestrated network of several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these pathways and serve not only as the prime site of cellular energy harvesting; but also as the producer of many key metabolic intermediates. The sirtuins are a family of NAD(+)-dependent enzymes, which have a crucial role in the cellular adaptation to metabolic stress. The mitochondria! sirtuins SIRT3, SIRT4 and SIRT5 together with the. nuclear SIRT1 regulate several aspects of mitochondrial physiology by controlling post-translational modifications of mitochondrial protein and transcription of mitochondrial genes. Here we discuss current knowledge how mitochondrial sirtuins and SIRT1 govera mitochondrial processes involved in different metabolic pathways. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：759 / 770

页数：12

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