Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

被引：5
作者：
Park, Sehee [1 ,2 ]
Kim, Jin Il [1 ,2 ]
Lee, Ilseob [1 ,2 ]
Lee, Sangmoo [1 ,2 ]
Hwang, Min-Woong [1 ,2 ]
Bae, Joon-Yong [1 ,2 ]
Heo, Jun [1 ,2 ]
Lim, Eun-Joo [3 ]
Seok, Won-Seok [3 ]
Cheong, Hee Jin [4 ]
Song, Joon Young [4 ]
Kim, Woo Joo [4 ]
Park, Man-Seong [1 ,2 ]
机构：
[1] Hallym Univ, Dept Microbiol, Chunchon 200702, South Korea
[2] Hallym Univ, Ctr Med Sci Res, Coll Med, Chunchon 200702, South Korea
[3] Gangwon Inst Hlth & Environm, Infect Dis Invest Div, Chunchon 200820, South Korea
[4] Korea Univ, Div Infect Dis, Guro Hosp, Coll Med, Seoul 152703, South Korea
来源：
JOURNAL OF MICROBIOLOGY | 2012年 / 50卷 / 06期
关键词：
influenza; neuraminidase; oseltamivir; A VIRUSES; RESISTANCE; H1N1; SURVEILLANCE;
D O I：
10.1007/s12275-012-2541-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
During the 2009-2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.
引用
收藏
页码：1067 / 1070
页数：4
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