Material Properties of Rat Middle Cerebral Arteries at High Strain Rates

被引：18

作者：

Bell, E. David ^{[1
]}

Converse, Matthew ^{[2
]}

Mao, Haojie ^{[3
]}

Unnikrishnan, Ginu ^{[3
]}

Reifman, Jaques ^{[3
]}

Monson, Kenneth L. ^{[1
,2
]}

机构：

[1] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Mech Engn, 1495 E 100 S,MEK 1550, Salt Lake City, UT 84112 USA

[3] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def, Biotechnol High Performance Comp Software Applica, Frederick, MD 21702 USA

来源：

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2018年 / 140卷 / 07期

关键词：

traumatic brain injury; blast injury; blood vessel mechanical properties; high strain rate testing; TRAUMATIC BRAIN-INJURY; FAILURE PROPERTIES; SUBFAILURE; HEAD;

D O I：

10.1115/1.4039625

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Traumatic brain injury (TBI), resulting from either impact-or nonimpact blast-related mechanisms, is a devastating cause of death and disability. The cerebral blood vessels, which provide critical support for brain tissue in both health and disease, are commonly injured in TBI. However, little is known about how vessels respond to traumatic loading, particularly at rates relevant to blast. To better understand vessel responses to trauma, the objective of this project was to characterize the high-rate response of passive cerebral arteries. Rat middle cerebral arteries (MCAs) were isolated and subjected to high-rate deformation in the axial direction. Vessels were perfused at physiological pressures and stretched to failure at strain rates ranging from approximately 100 to 1300 s(-1). Although both in vivo stiffness and failure stress increased significantly with strain rate, failure stretch did not depend on rate.

引用

页数：7