Adjuvant Therapy in Gastric Cancer: What Is The Optimal Approach?

被引:6
|
作者
Taketa, Takashi [1 ]
Sudo, Kazuki [1 ]
Wadhawa, Roopma [1 ]
Blum, Mariela M. [1 ]
Ajani, Jaffer A. [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Unit 426, Houston, TX 77030 USA
关键词
Gastric cancer; Adjuvant therapy; Preoperative; Postoperative; Biomarker; PHASE-III TRIAL; PERIOPERATIVE CHEMOTHERAPY; RANDOMIZED-TRIAL; SURGERY; ADENOCARCINOMA; 5-FLUOROURACIL; CISPLATIN; CHEMORADIOTHERAPY; IMPACT; CHEMORADIATION;
D O I
10.1007/s11912-013-0298-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Gastric cancer confers a poor prognosis even when diagnosed as localized disease. Multimodality therapy improves the cure rate of patients with localized cancer. However, adjunctive therapeutic approaches differ in different regions of the world. This review focuses on the current standards and unresolved issues based on updated literature on therapy for localized gastric cancer. In the USA, the Intergroup 0116 trial established the use of postoperative chemoradiotherapy as a standard for patients who have surgery first for treatment of gastric cancer. In Europe, the MAGIC trial investigating perioperative chemotherapy demonstrated a survival benefit for gastric cancer patients. Finally, in Asia, the ACTS-GC and CLASSIC trials investigating postoperative chemotherapy established this as the standard of care after primary surgery that included D2 dissection. It is clear, however, that surgery alone is insufficient to achieve the highest possible cure rates.
引用
收藏
页码:146 / 151
页数:6
相关论文
共 50 条
  • [21] Updated Adjuvant Chemotherapy for Gastric Cancer
    Takayama, Toshizo
    Tsuji, Yasushi
    JOURNAL OF CLINICAL MEDICINE, 2023, 12 (21)
  • [22] The necessity of adjuvant radiotherapy for locally advanced gastric cancer in China
    Yang, Yongqiang
    Xing, Pengfei
    Zhou, Ning
    Wu, Yongyou
    Zhang, Liyuan
    Tian, Ye
    TRANSLATIONAL CANCER RESEARCH, 2019, 8 (02) : 676 - 682
  • [23] Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma
    Zhu, Rebecca
    Liu, Fangfang
    Grisotti, Gabriella
    Perez-Irizarry, Javier
    Salem, Ronald R.
    Cha, Charles H.
    Johung, Kimberly L.
    Boffa, Daniel J.
    Zhang, Yawei
    Khan, Sajid A.
    JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2018, 9 (03) : 517 - +
  • [24] What make differences in the outcome of adjuvant treatments for resected gastric cancer?
    Nakajima, Toshifusa
    Fujii, Masashi
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (33) : 11567 - 11573
  • [25] Adjuvant therapy for locally advanced gastric cancer
    Toru Aoyama
    Takaki Yoshikawa
    Surgery Today, 2017, 47 : 1295 - 1302
  • [26] Neoadjuvant and Adjuvant Therapy Approaches to Gastric Cancer
    Caroline Fong
    Edwina Johnston
    Naureen Starling
    Current Treatment Options in Oncology, 2022, 23 : 1247 - 1268
  • [27] Optimizing adjuvant therapies for the treatment of gastric cancer: with a special focus on Asia
    Sasako, Mitsuru
    EXPERT REVIEW OF ANTICANCER THERAPY, 2019, 19 (11) : 939 - 945
  • [28] Implications of Lymph Node Staging on Selection of Adjuvant Therapy for Gastric Cancer in the United States A Propensity Score-matched Analysis
    Datta, Jashodeep
    McMillan, Matthew T.
    Ecker, Brett L.
    Karakousis, Giorgos C.
    Mamtani, Ronac
    Plastaras, John P.
    Giantonio, Bruce J.
    Drebin, Jeffrey A.
    Dempsey, Daniel T.
    Fraker, Douglas L.
    Roses, Robert E.
    ANNALS OF SURGERY, 2016, 263 (02) : 298 - 305
  • [29] Optimal Timing for Postsurgical Adjuvant Therapy in Patients with Gastric Cancer: A Propensity Score Matching Study
    Huang, Shih-Ming
    Chen, Yen-Chao
    Chen, Wan-Yu
    Yang, Lan-Yan
    Tsan, Din-Li
    Tsang, Ngan-Ming
    Yap, Wing-Keen
    Tsai, Chien-Sheng
    Leung, Wai-Man
    Hong, Ji-Hong
    Chang, Joseph Tung-Chieh
    Yeh, Ta-Sen
    Wu, Tsung-Han
    Chen, Yi-Chan
    Lin, Yun-Hsuan
    Huang, Bing-Shen
    JOURNAL OF CANCER, 2019, 10 (02): : 332 - 340
  • [30] Adjuvant and palliative therapy of pancreatic cancer
    Oettle, H.
    Pelzer, U.
    Stieler, J.
    Riess, H.
    ONKOLOGE, 2010, 16 (06): : 43 - 51