Olfactory event-related potentials in a functionally anosmic patient with arrested hydrocephalus

被引:1
作者
Caminiti, Fabrizia [1 ]
Ciurleo, Rosella [1 ]
De Salvo, Simona [1 ]
Galletti, Francesco [2 ]
Bramanti, Placido [1 ]
Marino, Silvia [1 ]
机构
[1] IRCCS Ctr Neurol Bonino Pulejo, SS 113,Via Palermo, I-98124 Messina, Italy
[2] Univ Messina, Dept Otorhinolaryngol, Messina, Italy
关键词
Fronto-temporal area; hydrocephalus; hyposmia; magnetic resonance imaging; olfactometer; olfactory bulb; olfactory dysfunction; olfactory event-related potentials; neuroplasticity; rostral-medial temporal area; ODOR DISCRIMINATION; BULB VOLUME; IDENTIFICATION; TESTS;
D O I
10.1177/0300060519826850
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Hydrocephalus is one of the lesser known causes of central olfactory loss. The pathogenesis of hydrocephalus involves the olfactory bulbs or tracts, and more rarely, other frontotemporal cortical regions. We describe a case of olfactory dysfunction in a macrocephalic 63-year-old female patient with arrested hydrocephalus. Her olfactory function was assessed by using the Sniffin' Sticks test, olfactory event-related potentials (OERPs), and 3-Tesla magnetic resonance imaging (MRI). An OERP examination suggested partial impairment of the central olfactory pathways and central parietal regions where OERP amplitude is maximal. Indeed, we found an evident olfactory potential trace with an increased latency only on Pz derivation. However, structural MRI showed important cortical brain thinning and large expansion of the third ventricle, with evident damage of the olfactory frontotemporal areas. The Sniffin' Sticks test and MRI supported the diagnosis of anosmia, while OERP findings indicated partial preservation of olfactory function, likely due to an adaptation of the central olfactory system. These findings highlight the importance of a multi-integrated approach to detect olfactory impairment.
引用
收藏
页码:1353 / 1358
页数:6
相关论文
共 10 条
  • [1] Evaluation of olfactory dysfunction in neurodegenerative diseases
    Barresi, Marina
    Ciurleo, Rosella
    Giacoppo, Sabrina
    Cuzzola, Valeria Foti
    Celi, Debora
    Bramanti, Placido
    Marino, Silvia
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2012, 323 (1-2) : 16 - 24
  • [2] Post-traumatic olfactory loss: Psychophysical, electrophysiological and neuroradiological findings in three single case studies
    Caminiti, Fabrizia
    Ciurleo, Rosella
    De Salvo, Simona
    Bramanti, Placido
    Marino, Silvia
    [J]. BRAIN INJURY, 2014, 28 (13-14) : 1776 - 1780
  • [3] Detection of Olfactory Dysfunction Using Olfactory Event Related Potentials in Young Patients with Multiple Sclerosis
    Caminiti, Fabrizia
    De Salvo, Simona
    De Cola, Maria Cristina
    Russo, Margherita
    Bramanti, Placido
    Marino, Silvia
    Ciurleo, Rosella
    [J]. PLOS ONE, 2014, 9 (07):
  • [4] Olfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapy
    Galletti, B.
    Santoro, R.
    Mannella, V. K.
    Caminiti, F.
    Bonanno, L.
    de Salvo, S.
    Cammaroto, G.
    Galletti, F.
    [J]. JOURNAL OF LARYNGOLOGY AND OTOLOGY, 2016, 130 (05) : 453 - 461
  • [5] Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects
    Hummel, T.
    Kobal, G.
    Gudziol, H.
    Mackay-Sim, A.
    [J]. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2007, 264 (03) : 237 - 243
  • [6] Correlation between olfactory bulb volume and olfactory function in children and adolescents
    Hummel, T.
    Smitka, M.
    Puschmann, S.
    Gerber, J. C.
    Schaal, B.
    Buschhueter, D.
    [J]. EXPERIMENTAL BRAIN RESEARCH, 2011, 214 (02) : 285 - 291
  • [7] Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds
    Kobal, G
    Klimek, L
    Wolfensberger, M
    Gudziol, H
    Temmel, A
    Owen, CM
    Seeber, H
    Pauli, E
    Hummel, T
    [J]. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2000, 257 (04) : 205 - 211
  • [8] Olfactory ability in normal pressure hydrocephalus as Alzheimer's disease and healthy controls
    Passler, Jesse S.
    Doty, Richard L.
    Dolske, Michelle C.
    Louis, Phillip G. St.
    Basignani, Cherlynn
    Pepe, Julie W.
    Bushnev, Sergey
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 372 : 217 - 219
  • [9] Olfactory bulb volume in patients with idiopathic normal pressure hydrocephalus
    Podlesek, Dino
    Leimert, Mario
    Schuster, Benno
    Gerber, Johannes
    Schackert, Gabriele
    Kirsch, Matthias
    Hummel, Thomas
    [J]. NEURORADIOLOGY, 2012, 54 (11) : 1229 - 1233
  • [10] Assessment of olfactory and trigeminal function using chemosensory event-related potentials
    Rombaux, P.
    Mouraux, A.
    Bertrand, B.
    Guerit, J. M.
    Hummel, T.
    [J]. NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, 2006, 36 (02): : 53 - 62