Intestinal Stem Cell Aging

被引：0
|
作者：
Sperka, Tobias [1 ]
Rudolph, Karl Lenhard [1 ]
机构：
[1] Univ Ulm, Inst Mol Med, Albert Einstein Allee 11, DE-89081 Ulm, Germany
来源：
MOLECULAR MECHANISMS OF ADULT STEM CELL AGING | 2010年 / 1卷
关键词：
TELOMERE-DYSFUNCTIONAL MICE; EXTENDS LIFE-SPAN; DNA-DAMAGE; GASTROINTESTINAL-TRACT; COLORECTAL-CANCER; OXIDATIVE STRESS; SELF-RENEWAL; MOUSE TELOMERASE; ISCHEMIC COLITIS; PROGENITOR CELLS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The intestinal epithelium is one of the most rapidly renewing tissues in the human organism. This remarkably high capacity of regeneration requires the maintenance of functional stem cells. Intestinal stem cells are located in the crypts of Lieberkuhn, the basal intestinal crypts. In this chapter, we summarize current knowledge on intestinal stem cells. In addition, we summarize reports from the Else Kroner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging indicating that molecular alterations in intestinal stem cells occur during aging and can limit maintenance and function of the intestine. copyright (C) 2010 S. Karger AG, Basel
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收藏
页码：63 / +
页数：5
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