Stereocontrolled synthesis of the enantiomers of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)-propyl]-pyrrolidin-2-one

被引：17
|
作者：
Kulig, K
Holzgrabe, U
Malawska, B
机构：
[1] Jagiellonian Univ, Dept Pharmaceut Chem, Coll Med, PL-30688 Krakow, Poland
[2] Univ Wurzburg, Inst Pharm & Lebensmittelchem, D-97074 Wurzburg, Germany
来源：
TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 18期
关键词：
D O I：
10.1016/S0957-4166(01)00390-1
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The asymmetric synthesis of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)-propyl]-pyrrolidin-2-one 1 is described. Enantiomers of compound I were obtained using the Sharpless asymmetric dihydroxylation (AD) or hydrolytic kinetic resolution (HKR) methods. The enantiomers of compound 1. which were obtained by HKR had higher enantiomeric excesses than those which were synthesized by AD and epoxidation. The enantiomeric purity of the synthesized compounds was determinated by capillary electrophoresis. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2533 / 2536
页数：4
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