Visuospatial Perception: An Emerging Biomarker for Alzheimer's Disease

被引：76

作者：

Mandal, Pravat K. ^{[1
,2
]}

Joshi, Jitesh ^{[2
]}

Saharan, Sumiti ^{[2
]}

机构：

[1] Dept Radiol, Baltimore, MD USA

[2] Natl Brain Res Ctr, Neurospect & Neuroimaging Lab, Gurgaon, India

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2012年 / 31卷

关键词：

Alzheimer's disease; biomarker; functional magnetic resonance imaging; mild cognitive impairment; visuospatial perception; MILD COGNITIVE IMPAIRMENT; POSTERIOR CORTICAL ATROPHY; HUMAN VISUAL-CORTEX; HUMAN EXTRASTRIATE CORTEX; OPTICAL COHERENCE TOMOGRAPHY; BINOCULAR DEPTH-PERCEPTION; CLOCK DRAWING PERFORMANCE; CEREBRAL-BLOOD-FLOW; NERVE-FIBER LAYER; PARIETAL CORTEX;

D O I：

10.3233/JAD-2012-120901

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In recent years, the focus of research on Alzheimer's disease (AD) has shifted toward finding reliable diagnostic biomarkers that enable accurate detection of mild cognitive impairment (MCI) as well as AD. Functional magnetic resonance imaging (fMRI) has the potential to identify functional changes in the preclinical stages of AD. In addition to the cardinal deficits in memory, deficits in visuospatial cognition are pervasive in AD. Recent neurophysiological and imaging studies have revealed that changes in visuospatial perception (VSP) functions can be detected in the early stages of AD. This review highlights the scope of VSP functional alterations as a biomarker for AD. We describe the neuroanatomical regions involved in the processing of various VSP tasks, and discuss the effect of AD on these regions from a pathological as well as a functional point of view. A comprehensive synopsis of the existing fMRI literature that has assessed VSP in patients with MCI and AD has been provided. The diagnostic scope of monitoring the brain activation correlates of VSP processing in AD is discussed

引用

页码：S117 / S135

页数：19

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