The effects of environmental factors on the virulence of Trichomonas vaginalis

被引：75

作者：

Figueroa-Angulo, Elisa E. ^{[1
]}

Rendon-Gandarilla, Francisco J. ^{[1
]}

Puente-Rivera, Jonathan ^{[1
]}

Calla-Choque, Jaeson S. ^{[1
]}

Cardenas-Guerra, Rosa E. ^{[2
]}

Ortega-Lopez, Jaime ^{[2
]}

Quintas-Granados, Laura I. ^{[3
]}

Elizbeth Alvarez-Sanchez, M. ^{[3
]}

Arroyo, Rossana ^{[1
]}

机构：

[1] Ctr Invest & Estudios Avanzados Inst Politecn Nac, Dept Infect & Patogenesis Mol, Mexico City 07360, DF, Mexico

[2] Ctr Invest & Estudios Avanzados Inst Politecn Nac, Dept Biotecnol & Bioingn, Mexico City 07360, DF, Mexico

[3] Univ Autonoma Ciudad Mexico, Mexico City 03100, DF, Mexico

来源：

MICROBES AND INFECTION | 2012年 / 14卷 / 15期

关键词：

Trichomonas vaginalis; Virulence; Iron; Cell contact; Zinc; Polyamines; PYRUVATE-FERREDOXIN OXIDOREDUCTASE; EPITHELIAL-CELLS; TRANSCRIPTIONAL REGULATION; CYSTEINE PROTEASES; BINDING PROTEIN; GENE-EXPRESSION; AP65-1; GENE; IRON; SURFACE; ADHERENCE;

D O I：

10.1016/j.micinf.2012.09.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review focused on potential regulatory mechanisms of Trichomonas vaginalis virulence properties, cytoadherence, cytotoxicity, phagocytosis, hemolysis, induction of apoptosis, and immune evasion in response to environmental factors of the human urogenital tract, iron, zinc, and polyamines. Understanding the multifactorial nature of trichomonal pathogenesis and its regulation may help to unravel the survival strategies of trichomonads and to implement prevention policies, opportune diagnosis, and alternative treatments for control of trichomoniasis. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：1411 / 1427

页数：17

共 87 条

[1]

ALDERETE JF, 1984, BRIT J VENER DIS, V60, P99

[2] Iron modulates phenotypic variation and phosphorylation of P270 in double-stranded RNA virus-infected Trichomonas vaginalis [J].

Alderete, JF .

INFECTION AND IMMUNITY, 1999, 67 (08) :4298-4302

[3] Enzymes on microbial pathogens and Trichomonas vaginalis:: molecular mimicry and functional diversity [J].

Alderete, JF ;

Millsap, KW ;

Lehker, MW ;

Benchimol, M .

CELLULAR MICROBIOLOGY, 2001, 3 (06) :359-370

[4] Negative iron regulation of the CP65 cysteine proteinase cytotoxicity in Trichomonas vaginalis [J].

Alvarez-Sanchez, Maria Elizbeth ;

Solano-Gonzalez, Eduardo ;

Yanez-Gomez, Carmina ;

Arroyo, Rossana .

MICROBES AND INFECTION, 2007, 9 (14-15) :1597-1605

[5] A novel cysteine proteinase (CP65) of Trichomonas vaginalis involved in cytotoxicity [J].

Alvarez-Sánchez, ME ;

Avila-González, L ;

Becerril-García, C ;

Fattel-Facenda, LV ;

Ortega-López, J ;

Arroyo, R .

MICROBIAL PATHOGENESIS, 2000, 28 (04) :193-202

[6] MOLECULAR-BASIS OF HOST EPITHELIAL-CELL RECOGNITION BY TRICHOMONAS-VAGINALIS [J].

ARROYO, R ;

ENGBRING, J ;

ALDERETE, JF .

MOLECULAR MICROBIOLOGY, 1992, 6 (07) :853-862

[7]

Arroyo R, 1995, Arch Med Res, V26, P279

[8] TRICHOMONAS-VAGINALIS SURFACE PROTEINASE ACTIVITY IS NECESSARY FOR PARASITE ADHERENCE TO EPITHELIAL-CELLS [J].

ARROYO, R ;

ALDERETE, JF .

INFECTION AND IMMUNITY, 1989, 57 (10) :2991-2997

[9] SIGNALING OF TRICHOMONAS-VAGINALIS FOR AMEBOID TRANSFORMATION AND ADHESIN SYNTHESIS FOLLOWS CYTOADHERENCE [J].

ARROYO, R ;

GONZALEZROBLES, A ;

MARTINEZPALOMO, A ;

ALDERETE, JF .

MOLECULAR MICROBIOLOGY, 1993, 7 (02) :299-309

[10] Trichomonas vaginalis lipophosphoglycan mutants have reduced adherence and cytotoxicity to human ectocervical cells [J].

Bastida-Corcuera, FD ;

Okumura, CY ;

Colocoussi, A ;

Johnson, PJ .

EUKARYOTIC CELL, 2005, 4 (11) :1951-1958

← 1 2 3 4 5 6 7 8 9 →