Neuromuscular activity of Bothrops alcatraz snake venom in chick biventer cervicis preparations

被引：6
作者：
de Moraes, Delkia Seabra [1 ]
de Abreu, Valdemir Aparecido [1 ,4 ]
Rostelato-Ferreira, Sandro [1 ]
Leite, Gildo B. [1 ]
da Cruz-Hoefling, Maria Alice [2 ]
Travaglia-Cardoso, Silvia R. [3 ]
Hyslop, Stephen [1 ]
Rodrigues-Simioni, Lea [1 ]
机构：
[1] State Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, BR-13083970 Campinas, SP, Brazil
[2] State Univ Campinas UNICAMP, Inst Biol, Dept Histol & Embryol, BR-13083970 Campinas, SP, Brazil
[3] Inst Butantan, Herpetol Lab, BR-1500 Sao Paulo, Brazil
[4] Ctr Univ Adventista UNASP, Sao Paulo, Brazil
来源：
TOXICON | 2012年 / 59卷 / 02期
关键词：
Bothrops alcatraz; Myotoxicity; Neuromuscular blockade; Neutralization; Nicotinic receptors; Snake venom; PHOSPHOLIPASE A(2); PRESYNAPTIC ACTION; MOUSE; NEUTRALIZATION; MYOTOXINS; PITVIPER; EFFICACY;
D O I：
10.1016/j.toxicon.2011.11.011
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Venom (10-100 mu g/ml) from Bothrops alcatraz, a pitviper from the Alcatrazes Archipelago off the coast of southeastern Brazil, caused progressive, irreversible neuromuscular blockade in chick isolated biventer cervicis preparations. The venom also inhibited contractures to exogenous ACh (110 mu M) and KCl (20 mM), caused myofiber damage and increased creatine kinase release. Commercial bothropic antivenom raised against mainland Bothrops species neutralized the neuromuscular activity, depending on the venom concentration. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：294 / 299
页数：6
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