Emerging concepts on the role of exosomes in lipid metabolic diseases

被引：64
|
作者：
Record, Michel [1 ,2 ,3 ]
Poirot, Marc [1 ,2 ,3 ]
Silvente-Poirot, Sandrine [1 ,2 ,3 ]
机构：
[1] CHU Purpan, CRCT, Team Sterol Metab & Therapeut Innovat Oncol, INSERM UMR 1037, F-31300 Toulouse, France
[2] Inst Claudius Regaud, F-31052 Toulouse, France
[3] Univ Toulouse 3, F-31062 Toulouse, France
来源：
BIOCHIMIE | 2014年 / 96卷
关键词：
Phospholipases; Eicosanoids; CD36; Cholesterol epoxyde hydrolase (CHEH); Docosahexaenoic acid (DHA); Tamoxifen; Cancer; CHOLESTEROL-METABOLISM; DENDRITIC CELLS; TRANSCELLULAR BIOSYNTHESIS; MOLECULAR-MECHANISMS; SECRETED EXOSOMES; PHOSPHOLIPASE D2; BREAST-CANCER; VESICLES; ACID; TAMOXIFEN;
D O I：
10.1016/j.biochi.2013.06.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dysregulation of lipid metabolism involves cellular communication mediated by cell contacts or exchange of bioactive lipids bound to soluble carriers or to lipoproteins. An increasing field is that of cellular communication mediated by nanovesicles called exosomes. Those vesicles are released from an internal compartment of viable cells, circulate in all biological fluids and can transfer material from cell-to-cells. Involvement of exosome trafficking in the transcellular metabolism of eicosanoids and cholesterol-related diseases including cancer is developed hereafter. (C) 2013 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：67 / 74
页数：8
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