IgG4-related orbital disease: a meta-analysis and review

被引:101
作者
Andrew, Nicholas [1 ,2 ]
Kearney, Daniel [3 ]
Selva, Dinesh [1 ,2 ]
机构
[1] Univ Adelaide, South Australian Inst Ophthalmol, Adelaide, SA, Australia
[2] Univ Adelaide, Dept Ophthalmol & Visual Sci, Adelaide, SA, Australia
[3] Dept Surg Pathol, Inst Med & Vet Sci, Adelaide, SA, Australia
关键词
dacryoadenitis; IgG4; IgG4-related disease; IgG4-related orbital disease; orbital; review; LYMPHOID-TISSUE LYMPHOMA; SCLEROSING DISEASE; EXTRAPANCREATIC LESIONS; AUTOIMMUNE PANCREATITIS; SYSTEMIC-DISEASE; MIKULICZS-DISEASE; PLASMA-CELLS; IGG4; INFLAMMATION; DACRYOADENITIS;
D O I
10.1111/j.1755-3768.2012.02526.x
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
IgG4-related orbital disease (IgG4-ROD) is a recently described condition that may account for a significant proportion of idiopathic lymphoplasmacytic or sclerotic orbital lesions. This study is the first meta-analysis of published cases and reveals several differences between IgG4-related disease affecting the orbit and that affecting the pancreas. IgG4-ROD affects a slightly younger group of patients, affects men and women approximately equally, is commonly associated with salivary gland lesions, is associated with a relatively higher serum IgG4 and may confer an increased risk of non-Hodgkin Lymphoma. Its pathogenesis may involve an immune response to antigen exposure in the upper aerodigestive tract.
引用
收藏
页码:694 / 700
页数:7
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