Efficient Phosphodiester Cleaving Nanozymes Resulting from Multivalency and Local Medium Polarity Control

被引：96
作者：
Diez-Castellnou, Marta [1 ]
Mancin, Fabrizio [1 ]
Scrimin, Paolo [1 ]
机构：
[1] Univ Padua, Dept Chem Sci, I-35131 Padua, Italy
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 04期
基金：
欧盟第七框架计划;
关键词：
DINUCLEAR ZN(II) COMPLEX; RNA MODELS; CLEAVAGE; DNA; CATALYSIS; WATER; HYDROLYSIS; NANOPARTICLES; MECHANISM; ENZYMES;
D O I：
10.1021/ja411969e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The self-organization of Zn(II) complexes on the surface of 1.6-nm diameter gold nanoparticles (nanozymes) allows the spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA model substrate. We show that by tuning the structure of the nanoparticle-coating monolayer, it is possible to decrease the polarity of the reaction site, and this in turn generates remarkable increments of the cleavage efficiency.
引用
收藏
页码：1158 / 1161
页数：4
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