Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy

被引：167

作者：

Davis, Kathryn Adamiak ^{[1
]}

Nanga, Ravi Prakash Reddy ^{[2
]}

Das, Sandhitsu ^{[3
]}

Chen, Stephanie H. ^{[1
]}

Hadar, Peter N. ^{[1
]}

Pollard, John R. ^{[1
]}

Lucas, Timothy H. ^{[4
]}

Shinohara, Russell T. ^{[5
]}

Litt, Brian ^{[1
]}

Hariharan, Hari ^{[2
]}

Elliott, Mark A. ^{[2
]}

Detre, John A. ^{[2
]}

Reddy, Ravinder ^{[2
]}

机构：

[1] Hosp Univ Penn, Dept Neurol, Penn Epilepsy Ctr, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Radiol, Ctr Magnet Resonance & Opt Imaging, Philadelphia, PA 19104 USA

[3] Univ Penn, Penn Image Comp & Sci Lab, Philadelphia, PA 19104 USA

[4] Hosp Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2015年 / 7卷 / 309期

关键词：

MAGNETIC-RESONANCE-SPECTROSCOPY; AMINO-ACID LEVELS; QUALITY-OF-LIFE; REFRACTORY EPILEPSY; IN-VIVO; EXTRACELLULAR GLUTAMATE; SEIZURE REMISSION; HIPPOCAMPUS; SURGERY; MRI;

D O I：

10.1126/scitranslmed.aaa7095

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

When neuroimaging reveals a brain lesion, drug-resistant epilepsy patients show better outcomes after resective surgery than do the one-third of drug-resistant epilepsy patients who have normal brain magnetic resonance imaging (MRI). We applied a glutamate imaging method, GluCEST (glutamate chemical exchange saturation transfer), to patients with nonlesional temporal lobe epilepsy based on conventional MRI. GluCEST correctly lateralized the temporal lobe seizure focus on visual and quantitative analyses in all patients. MR spectra, available for a subset of patients and controls, corroborated the GluCEST findings. Hippocampal volumes were not significantly different between hemispheres. GluCEST allowed high-resolution functional imaging of brain glutamate and has potential to identify the epileptic focus in patients previously deemed nonlesional. This method may lead to improved clinical outcomes for temporal lobe epilepsy as well as other localization-related epilepsies.

引用

页数：7

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