The molecular and clinicopathologic characteristics of bilateral breast cancer

被引：12
|
作者：
Chen, S. F. [1 ]
Du, C. W. [1 ]
Yang, P. [1 ]
Zhang, H. W. [1 ]
Kwan, M. [2 ]
Zhang, G. J. [3 ,4 ]
机构：
[1] Shantou Univ, Coll Med, Canc Hosp, Dept Med Oncol, Shantou 515031, Peoples R China
[2] Univ Hong Kong, Dept Pathol, Liver Canc & Hepatitis Res Lab, Hong Kong, Hong Kong, Peoples R China
[3] Shantou Univ, Coll Med, Canc Hosp, Breast Ctr, Shantou 515031, Peoples R China
[4] Shantou Univ, Coll Med, Canc Res Ctr, Shantou 515041, Peoples R China
来源：
SCIENTIFIC REPORTS | 2013年 / 3卷
基金：
中国国家自然科学基金;
关键词：
BONE METASTASES; BREAST CANCER; SURVIVAL; PROGNOSIS; DISEASE; CXCR4;
D O I：
10.1038/srep02590
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this study, we compared the clinicopathologic characteristics between the bilateral breast cancer (BiBC) and unilateral breast cancer (UBC) and investigated the role of CXC chemokine receptor type 4 (CXCR4) in BiBC. 48 BiBC and 1650 UBC were studied. We found BiBC patients were associated with family history of cancer, invasive lobular histology in the first tumor and an advanced nodal status as compared with UBC patients with. Survival analysis indicated that BiBC was not associated with impaired survival. The time interval between the development of first breast cancer and the contralateral cancer did not correlate with the prognosis. Patients with BiBC were more likely to have bone metastasis (P = 0.011) and visceral metastasis (P < 0.001) than those with UBC. However, CXCR4 was not found in any association with poor clinical outcome and increasing visceral metastasis in BiBC patients.
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页数：6
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