Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals

被引:71
|
作者
Kim, Minjeong [1 ]
Ko, Sung-Kyun [1 ]
Kim, Hyemi [1 ]
Shin, Injae [1 ]
Tae, Jinsung [1 ]
机构
[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea
关键词
REACTIVE OXYGEN; IN-VIVO; COUMARIN;
D O I
10.1039/c3cc44627a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new rhodamine fluorescent probe for monitoring (OH)-O-center dot has been developed based on the oxidative C-H abstraction reaction of rhodamine cyclic hydrazide. The probe exhibits excellent selectivity for (OH)-O-center dot with virtually no interference by other ROS/RNS species. Fluorescent imaging of A549 and RAW264.7 cells is also successfully demonstrated to detect intracellular (OH)-O-center dot in live cells.
引用
收藏
页码:7959 / 7961
页数:3
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